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    Rbm14 RNA binding motif protein 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170900, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Rbm14provided by RGD
    Official Full Name
    RNA binding motif protein 14provided by RGD
    Primary source
    RGD:620542
    See related
    Ensembl:ENSRNOG00000045568 AllianceGenome:RGD:620542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CoAA
    Summary
    Predicted to enable mRNA binding activity and nuclear receptor coactivator activity. Predicted to be involved in several processes, including activation of innate immune response; centriole assembly; and negative regulation of centriole replication. Predicted to act upstream of or within SMAD protein signal transduction. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Predicted to be active in nuclear speck. Orthologous to several human genes including RBM14-RBM4 (RBM14-RBM4 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 125.8), Adrenal (RPKM 116.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbm14 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211476298..211535077, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202076940..202105688, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220048740..220067124, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene Ras converting CAAX endopeptidase 1 Neighboring gene uncharacterized LOC102553046 Neighboring gene spectrin, beta, non-erythrocytic 2 Neighboring gene proteasome subunit alpha type-3-like Neighboring gene RNA binding motif protein 4B Neighboring gene RNA binding motif protein 4 Neighboring gene copper chaperone for superoxide dismutase Neighboring gene coiled-coil domain containing 87

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors. Li X, et al. J Cell Biochem, 2009 Oct 1. PMID 19585539, Free PMC Article
    2. The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons. Simpson MT, et al. Mol Cell Neurosci, 2015 Sep. PMID 26306672, Free PMC Article
    3. RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity. Shiratsuchi G, et al. EMBO J, 2015 Jan 2. PMID 25385835, Free PMC Article
    4. Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. Iwasaki T, et al. Endocrinology, 2005 Sep. PMID 15919756
    5. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). Iwasaki T, et al. J Biol Chem, 2001 Sep 7. PMID 11443112

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study idnetifed that the RBM14 as inhibitors of neurite outgrowth.
      Title: The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons.
    2. CoAA binds Runx2 and prevents Runx2 binding to DNA
      Title: Co-activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables splicing factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gastrulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of response to DNA integrity checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 14
    Names
    coactivator activator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133388.1 → NP_596879.1  RNA-binding protein 14

      See identical proteins and their annotated locations for NP_596879.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6HYZ2, A6HYZ3, M0R9Q1
      Related
      ENSRNOP00000066778.1, ENSRNOT00000072373.4
      Conserved Domains (3) summary
      TIGR01628
      Location:3 → 280
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12608
      Location:1 → 71
      RRM1_CoAA; RNA recognition motif 1 (RRM1) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)
      cd12609
      Location:79 → 146
      RRM2_CoAA; RNA recognition motif 2 (RRM2) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      211476298..211535077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272688.1 → XP_063128758.1  RNA-binding protein 14 isoform X2

    2. XM_063272714.1 → XP_063128784.1  RNA-binding protein 14 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A8X6, A0A8J8YGL2, A6HYY8

    3. XM_063272752.1 → XP_063128822.1  RNA-binding protein 14 isoform X4

    4. XM_039084839.2 → XP_038940767.1  RNA-binding protein 14 isoform X1

      UniProtKB/TrEMBL
      A6HYZ3, M0R3R6
      Related
      ENSRNOP00000064114.2
      Conserved Domains (3) summary
      TIGR01628
      Location:3 → 280
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12608
      Location:1 → 71
      RRM1_CoAA; RNA recognition motif 1 (RRM1) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)
      cd12609
      Location:79 → 146
      RRM2_CoAA; RNA recognition motif 2 (RRM2) found in vertebrate RRM-containing coactivator activator/modulator (CoAA)

    RNA

    1. XR_010057234.1 RNA Sequence

    2. XR_010057218.1 RNA Sequence

    3. XR_010057187.1 RNA Sequence

    4. XR_010057152.1 RNA Sequence

    5. XR_010057136.1 RNA Sequence

    6. XR_010057081.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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