Cadps2 calcium dependent secretion activator 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cadps2provided by RGD
Official Full Name: calcium dependent secretion activator 2provided by RGD
Primary source: RGD:1559440
See related: Ensembl:ENSRNOG00000007636 AllianceGenome:RGD:1559440
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559440
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in exocytosis and positive regulation of exocytosis. Predicted to act upstream of or within cellular response to starvation; hematopoietic stem cell homeostasis; and synaptic vesicle priming. Predicted to be located in several cellular components, including nucleoplasm; parallel fiber to Purkinje cell synapse; and synaptic membrane. Predicted to be active in glutamatergic synapse. Orthologous to human CADPS2 (calcium dependent secretion activator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 327.6), Lung (RPKM 69.6) and 6 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q22

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (52746054..53275252, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (51780415..52309641, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (50326447..50861161, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

AW550108 (e-PCR)
- UniSTS:207929

AU049560 (e-PCR)
- UniSTS:146007

RH137681 (e-PCR)
- UniSTS:219768

BE119864 (e-PCR)
- UniSTS:249288

PMC126259P3 (e-PCR)
- UniSTS:270538

GDB:1317954 (e-PCR)
- UniSTS:12511

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in dense core granule exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle priming	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
NOT located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: calcium-dependent secretion activator 2

Names: Ca++-dependent secretion activator 2; Ca2+ dependent secretion activator 2; Ca2+-dependent activator protein for secretion 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427791.1 → NP_001414720.1 calcium-dependent secretion activator 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

52746054..53275252 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285976.1 → XP_063142046.1 calcium-dependent secretion activator 2 isoform X4
XM_039108614.2 → XP_038964542.1 calcium-dependent secretion activator 2 isoform X8

UniProtKB/TrEMBL

A0A8I5ZKA3

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 892

DUF1041; Domain of Unknown Function (DUF1041)
XM_002729291.6 → XP_002729337.1 calcium-dependent secretion activator 2 isoform X7

See identical proteins and their annotated locations for XP_002729337.1

UniProtKB/TrEMBL

A0A8I5ZKA3

Conserved Domains (4) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam00169
Location:493 → 592

PH; PH domain

pfam06292
Location:802 → 892

DUF1041; Domain of Unknown Function (DUF1041)
XM_063285979.1 → XP_063142049.1 calcium-dependent secretion activator 2 isoform X10
XM_063285975.1 → XP_063142045.1 calcium-dependent secretion activator 2 isoform X3

UniProtKB/TrEMBL

A0A8I6AHC2
XM_063285977.1 → XP_063142047.1 calcium-dependent secretion activator 2 isoform X5
XM_063285973.1 → XP_063142043.1 calcium-dependent secretion activator 2 isoform X1
XM_039108612.2 → XP_038964540.1 calcium-dependent secretion activator 2 isoform X6

UniProtKB/TrEMBL

A0A8I5ZKA3

Related

ENSRNOP00000080739.1

Conserved Domains (3) summary

smart00239
Location:369 → 452

C2; Protein kinase C conserved region 2 (CalB)

cd01234
Location:485 → 604

PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

pfam06292
Location:802 → 899

DUF1041; Domain of Unknown Function (DUF1041)
XM_063285974.1 → XP_063142044.1 calcium-dependent secretion activator 2 isoform X2

UniProtKB/TrEMBL

A0A8I6GDI0, A6IE75
XM_063285978.1 → XP_063142048.1 calcium-dependent secretion activator 2 isoform X9