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    Mycl MYCL proto-oncogene, bHLH transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298506, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Myclprovided by RGD
    Official Full Name
    MYCL proto-oncogene, bHLH transcription factorprovided by RGD
    Primary source
    RGD:1588591
    See related
    Ensembl:ENSRNOG00000014259 AllianceGenome:RGD:1588591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lmyc1; Mycl1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of inner ear auditory receptor cell differentiation. Predicted to be located in chromosome and nucleoplasm. Orthologous to human MYCL (MYCL proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 61.3), Thymus (RPKM 34.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mycl in Genome Data Viewer
    Location:
    5q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (140559843..140566704)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (135274713..135281584)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (140691947..140698837)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cyclase associated actin cytoskeleton regulatory protein 1 Neighboring gene uncharacterized LOC100909490 Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid Neighboring gene tRNA isopentenyltransferase 1 Neighboring gene bone morphogenetic protein 8b Neighboring gene 3-oxoacid CoA transferase 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. N-Myc and L-Myc are essential for hair cell formation but not maintenance. Kopecky BJ, et al. Brain Res, 2012 Nov 12. PMID 23022312, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of inner ear auditory receptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein L-Myc
    Names
    Avian myelocytomatosis viral (v-myc) related oncogene homolog 1, lung carcinoma derived (Lmyc)
    protein L-Myc-1
    v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
    v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191763.3 → NP_001178692.1  protein L-Myc isoform 1

      See identical proteins and their annotated locations for NP_001178692.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IS13
      Conserved Domains (2) summary
      cd00083
      Location:284 → 338
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:2 → 219
      Myc_N; Myc amino-terminal region

    2. NM_001411603.2 → NP_001398532.1  protein L-Myc isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      G3V7T4
      Related
      ENSRNOP00000019101.4, ENSRNOT00000019101.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      140559843..140566704
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238795.5 → XP_006238857.1  protein L-Myc isoform X2

      See identical proteins and their annotated locations for XP_006238857.1

      UniProtKB/TrEMBL
      A6IS13
      Conserved Domains (2) summary
      cd00083
      Location:284 → 338
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam01056
      Location:2 → 219
      Myc_N; Myc amino-terminal region

    2. XM_039109610.2 → XP_038965538.1  protein L-Myc isoform X1

      Conserved Domains (2) summary
      cd11457
      Location:310 → 398
      bHLHzip_L-Myc; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins
      pfam01056
      Location:26 → 248
      Myc_N; Myc amino-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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