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    Gnpda2 glucosamine-6-phosphate deaminase 2 [ Mus musculus (house mouse) ]

    Gene ID: 67980, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Gnpda2provided by MGI
    Official Full Name
    glucosamine-6-phosphate deaminase 2provided by MGI
    Primary source
    MGI:MGI:1915230
    See related
    Ensembl:ENSMUSG00000029209 AllianceGenome:MGI:1915230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gnp2; Sb52; GNPDA; mKIAA4008; 4921523I18Rik; 4933412A11Rik
    Summary
    Predicted to enable glucosamine-6-phosphate deaminase activity and identical protein binding activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process and amino sugar catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human GNPDA2 (glucosamine-6-phosphate deaminase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 5.6), testis adult (RPKM 4.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gnpda2 in Genome Data Viewer
    Location:
    5 C3.1; 5 37.13 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (69732344..69749684, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (69574998..69592332, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4760 Neighboring gene STARR-seq mESC enhancer starr_13339 Neighboring gene Yip1 domain family, member 7 Neighboring gene GUF1 homolog, GTPase Neighboring gene predicted gene, 26044 Neighboring gene predicted gene, 23661

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two mammalian glucosamine-6-phosphate deaminases: a structural and genetic study. Arreola R, et al. FEBS Lett, 2003 Sep 11. PMID 12965206
    2. Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. West DB, et al. PLoS Genet, 2016 Feb. PMID 26839965, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4008

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glucosamine-6-phosphate deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosamine-6-phosphate deaminase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables glucosamine-6-phosphate deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucosamine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glucosamine-6-phosphate isomerase 2
    Names
    GNPDA 2
    glcN6P deaminase 2
    oscillin
    NP_001033104.1
    NP_001334292.1
    NP_001346168.1
    XP_011239068.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038015.2 → NP_001033104.1  glucosamine-6-phosphate isomerase 2 isoform 1

      See identical proteins and their annotated locations for NP_001033104.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC109186
      Consensus CDS
      CCDS19324.1
      UniProtKB/Swiss-Prot
      Q3TH02, Q9CRC9, Q9D457
      Related
      ENSMUSP00000031117.7, ENSMUST00000031117.13
      Conserved Domains (1) summary
      PRK00443
      Location:1 → 258
      nagB; glucosamine-6-phosphate deaminase; Provisional

    2. NM_001347363.1 → NP_001334292.1  glucosamine-6-phosphate isomerase 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC109186
      Consensus CDS
      CCDS84888.1
      UniProtKB/Swiss-Prot
      Q9CRC9
      Related
      ENSMUSP00000133490.2, ENSMUST00000173927.8
      Conserved Domains (1) summary
      cl00339
      Location:1 → 251
      SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

    3. NM_001359239.1 → NP_001346168.1  glucosamine-6-phosphate isomerase 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC109186, AK051596
      Consensus CDS
      CCDS89926.1
      UniProtKB/TrEMBL
      D3YWR1
      Related
      ENSMUSP00000112484.2, ENSMUST00000120789.8
      Conserved Domains (1) summary
      cl00339
      Location:1 → 253
      SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      69732344..69749684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240766.2 → XP_011239068.1  glucosamine-6-phosphate isomerase 2 isoform X1

      Conserved Domains (1) summary
      cl00339
      Location:1 → 139
      SugarP_isomerase; Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_027681.1: Suppressed sequence

      Description
      NM_027681.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRC9.1 GenPept UniProtKB/Swiss-Prot:Q9CRC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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