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    Larp1 La ribonucleoprotein 1, translational regulator [ Mus musculus (house mouse) ]

    Gene ID: 73158, updated on 8-May-2024

    Summary

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    Official Symbol
    Larp1provided by MGI
    Official Full Name
    La ribonucleoprotein 1, translational regulatorprovided by MGI
    Primary source
    MGI:MGI:1890165
    See related
    Ensembl:ENSMUSG00000037331 AllianceGenome:MGI:1890165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Larp; mKIAA0731; 1810024J12Rik; 3110040D16Rik
    Summary
    Predicted to enable eukaryotic initiation factor 4E binding activity; nucleic acid binding activity; and ribosomal small subunit binding activity. Predicted to be involved in several processes, including TORC1 signaling; cellular response to rapamycin; and posttranscriptional regulation of gene expression. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of TORC1 complex and polysome. Predicted to be active in cytoplasmic stress granule and cytosol. Predicted to colocalize with polysomal ribosome. Is expressed in several structures, including branchial arch; cranial ganglion; epithelium; future spinal cord; and limb bud. Orthologous to human LARP1 (La ribonucleoprotein 1, translational regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 51.6), genital fat pad adult (RPKM 17.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Larp1 in Genome Data Viewer
    Location:
    11 B1.3; 11 35.55 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (57899711..57952860)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (57973418..58062034)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33078 Neighboring gene VISTA enhancer mm849 Neighboring gene STARR-positive B cell enhancer ABC_E6988 Neighboring gene STARR-seq mESC enhancer starr_29589 Neighboring gene STARR-positive B cell enhancer ABC_E8407 Neighboring gene STARR-positive B cell enhancer ABC_E10676 Neighboring gene reduced expression 3 (Rex3) pseudogene Neighboring gene STARR-seq mESC enhancer starr_29598 Neighboring gene predicted gene, 51897 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene predicted gene 12247 Neighboring gene CCR4-NOT transcription complex, subunit 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1. Yonezu Y, et al. Biochem Biophys Res Commun, 2022 Aug 27. PMID 35716596
    2. The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1). Farooq Z, et al. J Biol Chem, 2022 Sep. PMID 35863436, Free PMC Article
    3. The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass. Werneck-de-Castro JP, et al. Sci Rep, 2021 Jan 22. PMID 33483593, Free PMC Article
    4. dlarp, a new candidate Hox target in Drosophila whose orthologue in mouse is expressed at sites of epithelium/mesenchymal interactions. Chauvet S, et al. Dev Dyn, 2000 Jul. PMID 10878606
    5. Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function. Vincentz JW, et al. Circ Res, 2019 Aug 30. PMID 31366290, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
      Title: The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).
    2. Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1.
      Title: Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1.
    3. The RNA-binding protein LARP1 is dispensable for pancreatic beta-cell function and mass.
      Title: The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA cap binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to rapamycin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-transcriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    la-related protein 1
    Names
    La ribonucleoprotein domain family, member 1
    la related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028451.1 → NP_082727.1  la-related protein 1

      See identical proteins and their annotated locations for NP_082727.1

      Status: VALIDATED

      Source sequence(s)
      AL672182
      Consensus CDS
      CCDS56771.1
      UniProtKB/Swiss-Prot
      A2AFQ8, J3QNB1, Q6ZQ58, Q7TSF7
      UniProtKB/TrEMBL
      Z4YJT3
      Related
      ENSMUSP00000136673.2, ENSMUST00000178636.2
      Conserved Domains (2) summary
      smart00684
      Location:903 → 941
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08034
      Location:379 → 451
      LARP_1_2; La RNA-binding domain proteins similar to La-related proteins 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      57899711..57952860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157022.1 → XP_036012915.1  la-related protein 1 isoform X2

      UniProtKB/TrEMBL
      Z4YJT3
      Conserved Domains (4) summary
      smart00684
      Location:725 → 763
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      PTZ00449
      Location:2 → 111
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG5193
      Location:171 → 355
      LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
      cl02755
      Location:201 → 273
      LAM; LA motif RNA-binding domain

    2. XM_006534334.4 → XP_006534397.2  la-related protein 1 isoform X1

      UniProtKB/TrEMBL
      Z4YJT3
      Conserved Domains (4) summary
      smart00684
      Location:795 → 833
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      PTZ00449
      Location:62 → 181
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG5193
      Location:241 → 425
      LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
      cl02755
      Location:271 → 343
      LAM; LA motif RNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQ58.3 GenPept UniProtKB/Swiss-Prot:Q6ZQ58

    Gene LinkOut

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