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    DAG1 dystroglycan 1 [ Bos taurus (cattle) ]

    Gene ID: 281439, updated on 6-Jun-2024

    Summary

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    Official Symbol
    DAG1provided by VGNC
    Official Full Name
    dystroglycan 1provided by VGNC
    Primary source
    VGNC:VGNC:27871
    See related
    BGD:BT12372; Ensembl:ENSBTAG00000011580
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    RAB7
    Orthologs
    human mouse all
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    Genomic context

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    See DAG1 in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (50614127..50662793, complement)

    Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene acylaminoacyl-peptide hydrolase Neighboring gene bassoon presynaptic cytomatrix protein Neighboring gene uncharacterized LOC112443525 Neighboring gene NEDD8-conjugating enzyme UBE2F-like Neighboring gene nicolin 1, tubulin polyglutamylase complex subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the transmembrane molecular architecture of the dystroglycan complex in schwann cells. Saito F, et al. J Biol Chem, 1999 Mar 19. PMID 10075729
    2. Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11. McDearmon EL, et al. FEBS Lett, 2006 Jun 12. PMID 16709410
    3. Dystroglycan is a dual receptor for agrin and laminin-2 in Schwann cell membrane. Yamada H, et al. J Biol Chem, 1996 Sep 20. PMID 8798547
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables laminin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in muscle attachment IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nerve development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of dystroglycan complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of dystrophin-associated glycoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dystroglycan 1
    Names
    RAB7, member RAS oncogene family
    dystrophin-associated glycoprotein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174162.1 → NP_776587.1  dystroglycan 1 precursor

      See identical proteins and their annotated locations for NP_776587.1

      Status: PROVISIONAL

      Source sequence(s)
      AB009079
      UniProtKB/Swiss-Prot
      O18738
      UniProtKB/TrEMBL
      F1N7D7
      Conserved Domains (3) summary
      cd11303
      Location:62 → 163
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:181 → 304
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      pfam05454
      Location:606 → 895
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      50614127..50662793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005222705.5 → XP_005222762.2  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      F1N7D7
      Conserved Domains (4) summary
      cd11303
      Location:62 → 163
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:181 → 304
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      pfam05454
      Location:606 → 895
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      cl26247
      Location:303 → 404
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    2. XM_024982387.2 → XP_024838155.1  dystroglycan 1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LQU4
      Related
      ENSBTAP00000059334.2, ENSBTAT00000074163.2
      Conserved Domains (5) summary
      cd11303
      Location:175 → 276
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:294 → 417
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      pfam05454
      Location:719 → 1008
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      cl26247
      Location:426 → 517
      DNA_pol3_delta2; DNA polymerase III, delta subunit
      cl27975
      Location:411 → 611
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

    3. XM_005222706.5 → XP_005222763.2  dystroglycan 1 isoform X1

      UniProtKB/TrEMBL
      F1N7D7
      Conserved Domains (4) summary
      cd11303
      Location:62 → 163
      Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
      cd11305
      Location:181 → 304
      alpha_DG_C; C-terminal domain of alpha dystroglycan
      pfam05454
      Location:606 → 895
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
      cl26247
      Location:303 → 404
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18738.1 GenPept UniProtKB/Swiss-Prot:O18738

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials