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    P4HB prolyl 4-hydroxylase subunit beta [ Bos taurus (cattle) ]

    Gene ID: 281373, updated on 5-May-2024

    Summary

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    Official Symbol
    P4HBprovided by VGNC
    Official Full Name
    prolyl 4-hydroxylase subunit betaprovided by VGNC
    Primary source
    VGNC:VGNC:32538
    See related
    BGD:BT18140; Ensembl:ENSBTAG00000006045
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    PDI
    Orthologs
    human mouse all
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    Genomic context

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    See P4HB in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (51034603..51044546)

    Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor alpha Neighboring gene proteasome assembly chaperone 3-like Neighboring gene protein phosphatase 1 regulatory subunit 27 Neighboring gene MAPK regulated corepressor interacting protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of membrane-associated thyroid hormone binding protein from bovine liver: its identity with protein disulphide isomerase. Yamauchi K, et al. Biochem Biophys Res Commun, 1987 Aug 14. PMID 3619939
    2. [Interaction of rotavirus with protein disulfide isomerase in vitro and cell system]. Calderón MN, et al. Biomedica, 2011 Mar. PMID 22159485
    3. Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex. Wetterau JR, et al. J Biol Chem, 1990 Jun 15. PMID 2351674
    4. Analysis of bovine mammary gland EST and functional annotation of the Bos taurus gene index. Sonstegard TS, et al. Mamm Genome, 2002 Jul. PMID 12140684
    5. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein disulfide-isomerase
    Names
    PDI (E.C.5.3.4.1)
    cellular thyroid hormone binding protein
    p55
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
    prolyl 4-hydroxylase beta polypeptide
    prolyl 4-hydroxylase, beta subunit
    NP_776560.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174135.3 → NP_776560.1  protein disulfide-isomerase precursor

      See identical proteins and their annotated locations for NP_776560.1

      Status: PROVISIONAL

      Source sequence(s)
      M17596
      UniProtKB/Swiss-Prot
      P05307
      UniProtKB/TrEMBL
      A6H7J6
      Related
      ENSBTAP00000007943.5, ENSBTAT00000007943.6
      Conserved Domains (5) summary
      cd02981
      Location:139 → 234
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02982
      Location:246 → 349
      PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:370 → 472
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      TIGR01130
      Location:26 → 476
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:31 → 135
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      51034603..51044546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05307.1 GenPept UniProtKB/Swiss-Prot:P05307

    Gene LinkOut

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