TIMP3 TIMP metallopeptidase inhibitor 3 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: TIMP3provided by VGNC
Official Full Name: TIMP metallopeptidase inhibitor 3provided by VGNC
Primary source: VGNC:VGNC:35872
See related: BGD:BT10620; Ensembl:ENSBTAG00000020638
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: TIMP-3
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	5	NC_037332.1 (71402333..71459972)

Chromosome 5 - NC_037332.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reactive oxygen species mediate TGF-beta1-induced TIMP-3 gene expression
Title: Transforming growth factor Beta1 induction of tissue inhibitor of metalloproteinases 3 in articular chondrocytes is mediated by reactive oxygen species.
TIMP3 mRNA expression level was upregulated by multidirectional articular motion.
Title: Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds.
TIMP3 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.
Title: Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.

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General gene information

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Markers

MARC_33481-33482:1054059206:1 (e-PCR)
- UniSTS:466709

MARC_33483-33484:1054059731:1 (e-PCR)
- UniSTS:466710

Timp3 (e-PCR), detects polymorphism
- UniSTS:265762

MARC_33751-33752:1055171673:1 (e-PCR)
- UniSTS:466779

MARC_33759-33760:1055173144:1 (e-PCR)
- UniSTS:466781

MARC_33767-33768:1055255100:1 (e-PCR)
- UniSTS:466784

MARC_33779-33780:1055265539:1 (e-PCR)
- UniSTS:466789

MARC_33781-33782:1055269009:1 (e-PCR)
- UniSTS:466790

ECD04505 (e-PCR)
- UniSTS:285577

D22S1555 (e-PCR)
- UniSTS:74903

TIMP3 (e-PCR)
- UniSTS:279194

D22S979E (e-PCR)
- UniSTS:88515

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protease binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to organic substance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: metalloproteinase inhibitor 3

Names: TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory); tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory); tissue inhibitor of metalloproteinases 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174473.4 → NP_776898.2 metalloproteinase inhibitor 3 precursor

See identical proteins and their annotated locations for NP_776898.2

Status: PROVISIONAL

Source sequence(s)

BC112663

UniProtKB/Swiss-Prot

P79121, Q2KIE9, Q9TVB2

Related

ENSBTAP00000027504.5, ENSBTAT00000027504.5

Conserved Domains (1) summary

cd03585
Location:24 → 200

NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...