Abhd17b abhydrolase domain containing 17B, depalmitoylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abhd17bprovided by RGD
Official Full Name: abhydrolase domain containing 17B, depalmitoylaseprovided by RGD
Primary source: RGD:1305246
See related: Ensembl:ENSRNOG00000012514 AllianceGenome:RGD:1305246
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cgi67l; Fam108b1; RGD1305246
Summary: Predicted to enable palmitoyl-(protein) hydrolase activity. Involved in regulation of postsynapse organization. Is active in glutamatergic synapse. Is anchored component of postsynaptic density membrane and anchored component of postsynaptic recycling endosome membrane. Orthologous to human ABHD17B (abhydrolase domain containing 17B, depalmitoylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 183.6), Brain (RPKM 176.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q51

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (228624821..228659254)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (219198294..219232733)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (239266140..239301133)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables palmitoyl-(protein) hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-(protein) hydrolase activity	IEA Inferred from Electronic Annotation more info
enables palmitoyl-(protein) hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in macromolecule depalmitoylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to microtubule	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to microtubule	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to endosome	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to endosome	ISO Inferred from Sequence Orthology more info
involved_in protein depalmitoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine maintenance	IEA Inferred from Electronic Annotation more info
involved_in regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to synapse	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization to synapse	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic recycling endosome membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha/beta hydrolase domain-containing protein 17B

Names: abhydrolase domain-containing protein 17B; abhydrolase domain-containing protein FAM108B1; family with sequence similarity 108, member B1; protein ABHD17B

NP_001014050.1

EC 3.1.2.22

XP_006231224.1

EC 3.1.2.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014028.1 → NP_001014050.1 alpha/beta hydrolase domain-containing protein 17B

See identical proteins and their annotated locations for NP_001014050.1

Status: PROVISIONAL

Source sequence(s)

BC079229

UniProtKB/Swiss-Prot

Q6AY17

UniProtKB/TrEMBL

A0A8I5ZUP2, A6I0M6

Related

ENSRNOP00000047508.2, ENSRNOT00000044486.4

Conserved Domains (1) summary

COG1073
Location:93 → 285

FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

228624821..228659254

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231162.5 → XP_006231224.1 alpha/beta hydrolase domain-containing protein 17B isoform X1

See identical proteins and their annotated locations for XP_006231224.1

UniProtKB/Swiss-Prot

Q6AY17

UniProtKB/TrEMBL

A0A8I5ZUP2, A6I0M6

Conserved Domains (1) summary

COG1073
Location:93 → 285

FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]