Atox1 antioxidant 1 copper chaperone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atox1provided by RGD
Official Full Name: antioxidant 1 copper chaperoneprovided by RGD
Primary source: RGD:621684
See related: Ensembl:ENSRNOG00000013118 AllianceGenome:RGD:621684
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Atx1
Summary: Enables ATPase binding activity. Involved in copper ion export; negative regulation of apoptotic process; and response to oxidative stress. Predicted to be active in cytosol. Orthologous to human ATOX1 (antioxidant 1 copper chaperone). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 596.4), Kidney (RPKM 378.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (40065525..40080627, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (39564855..39579892, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (40790850..40805886, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle.
Title: Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle.
these results suggest that Ctr1, DMT1, ATOX1 and ATP7A contribute to Cu transport at the blood-CSF barrier
Title: Mechanism of copper transport at the blood-cerebrospinal fluid barrier: influence of iron deficiency in an in vitro model.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236579

RH136058 (e-PCR)
- UniSTS:210053

RH129645 (e-PCR)
- UniSTS:212942

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables copper chaperone activity	IBA Inferred from Biological aspect of Ancestor more info
enables copper chaperone activity	IEA Inferred from Electronic Annotation more info
enables copper chaperone activity	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables copper-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables cuprous ion binding	IEA Inferred from Electronic Annotation more info
enables cuprous ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in copper ion export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in copper ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within copper ion transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular copper ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular copper ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: copper transport protein ATOX1

Names: ATX1 (antioxidant protein 1) homolog 1; ATX1 antioxidant protein 1 homolog; ATX1 homolog protein Rah1; metal transport protein ATX1

NP_445811.1

EC 6.2.1.2

XP_063126056.1

EC 6.2.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053359.2 → NP_445811.1 copper transport protein ATOX1

See identical proteins and their annotated locations for NP_445811.1

Status: VALIDATED

Source sequence(s)

AF177671, BI281905, BM392393

UniProtKB/Swiss-Prot

Q549B3, Q9WUC4

UniProtKB/TrEMBL

A0A8I6ASE1, A6HEM9

Related

ENSRNOP00000017588.5, ENSRNOT00000017588.7

Conserved Domains (1) summary

cd00371
Location:5 → 63

HMA; Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain ...