Psmc3ip PSMC3 interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psmc3ipprovided by RGD
Official Full Name: PSMC3 interacting proteinprovided by RGD
Primary source: RGD:621885
See related: Ensembl:ENSRNOG00000020022 AllianceGenome:RGD:621885
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gt198; Tbpip
Summary: Enables DNA binding domain binding activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Human ortholog(s) of this gene implicated in ovarian dysgenesis 3. Orthologous to human PSMC3IP (PSMC3 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 105.9), Thymus (RPKM 38.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86524546..86527764, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86024281..86027928, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89002109..89006075, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A005R24 (e-PCR)
- UniSTS:17359

RH136418 (e-PCR)
- UniSTS:210408

RH127869 (e-PCR)
- UniSTS:211179

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding domain binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear androgen receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear estrogen receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear glucocorticoid receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor coactivator activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables recombinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in homologous chromosome pairing at meiosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in homologous chromosome pairing at meiosis	IEA Inferred from Electronic Annotation more info
involved_in homologous chromosome pairing at meiosis	ISO Inferred from Sequence Orthology more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in meiotic joint molecule formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic strand invasion involved in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	TAS Traceable Author Statement more info	PubMed
involved_in reciprocal meiotic recombination	IEA Inferred from Electronic Annotation more info
involved_in reciprocal meiotic recombination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DNA recombinase auxiliary factor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in condensed nuclear chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homologous-pairing protein 2 homolog

Names: nuclear receptor coactivator GT198; proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein; proteasome 26S ATPase subunit 3-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134458.2 → NP_604453.2 homologous-pairing protein 2 homolog

Status: VALIDATED

Source sequence(s)

AF352812, CK840952

UniProtKB/Swiss-Prot

Q91ZY6

UniProtKB/TrEMBL

A6HJ83, G3V8N3

Related

ENSRNOP00000027159.4, ENSRNOT00000027159.7

Conserved Domains (2) summary

pfam07106
Location:12 → 74

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)

pfam18517
Location:154 → 210

LZ3wCH; Leucine zipper with capping helix domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86524546..86527764 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247249.5 → XP_006247311.1 homologous-pairing protein 2 homolog isoform X1

UniProtKB/TrEMBL

A6HJ83, G3V8N3

Conserved Domains (1) summary

pfam07106
Location:16 → 179

TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)