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    Adam34 a disintegrin and metallopeptidase domain 34 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685846, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Adam34provided by RGD
    Official Full Name
    a disintegrin and metallopeptidase domain 34provided by RGD
    Primary source
    RGD:1589040
    See related
    Ensembl:ENSRNOG00000038743 AllianceGenome:RGD:1589040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adam26b
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Adam34 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (55290008..55294201)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (48557385..48561744)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (51750790..51752939)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene endothelial differentiation-related factor 1, pseudogene 4 Neighboring gene a disintegrin and metalloprotease domain 34-like Neighboring gene calcium binding and coiled-coil domain 2, pseudogene 1 Neighboring gene uncharacterized LOC134482382 Neighboring gene a disintegrin and metallopeptidase domain 26A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    a disintegrin and metallopeptidase domain 34
    Names
    a disintegrin and metallopeptidase domain 26B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135090.2 → NP_001128562.1  a disintegrin and metallopeptidase domain 34 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      F1LMB6
      Related
      ENSRNOP00000055955.5, ENSRNOT00000059182.5
      Conserved Domains (4) summary
      smart00608
      Location:493 → 628
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:208 → 396
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:416 → 488
      Disintegrin
      pfam01562
      Location:44 → 160
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      55290008..55294201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094826.2 → XP_038950754.1  a disintegrin and metallopeptidase domain 34 isoform X1

      UniProtKB/TrEMBL
      F1LMB6
      Conserved Domains (4) summary
      smart00608
      Location:493 → 628
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:208 → 396
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:416 → 488
      Disintegrin
      pfam01562
      Location:44 → 160
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein Strain
    Heading Accession and Version

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