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    Pianp PILR alpha associated neural protein [ Mus musculus (house mouse) ]

    Gene ID: 319352, updated on 9-May-2024

    Summary

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    Official Symbol
    Pianpprovided by MGI
    Official Full Name
    PILR alpha associated neural proteinprovided by MGI
    Primary source
    MGI:MGI:2441908
    See related
    Ensembl:ENSMUSG00000030329 AllianceGenome:MGI:2441908
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Panp; C530028O21Rik
    Summary
    Predicted to be involved in regulation of immune response. Predicted to be located in basolateral plasma membrane. Predicted to be active in membrane. Used to study autism spectrum disorder. Orthologous to human PIANP (PILR alpha associated neural protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 36.2), cortex adult (RPKM 30.0) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pianp in Genome Data Viewer
    Location:
    6 F2; 6 59.17 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124973683..124980059)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124996720..125003096)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8969 Neighboring gene STARR-seq mESC enhancer starr_17317 Neighboring gene myeloid leukemia factor 2 Neighboring gene STARR-seq mESC enhancer starr_17318 Neighboring gene STARR-seq mESC enhancer starr_17319 Neighboring gene STARR-positive B cell enhancer ABC_E3682 Neighboring gene COP9 signalosome subunit 7A Neighboring gene predicted gene, 23851 Neighboring gene STARR-seq mESC enhancer starr_17320 Neighboring gene STARR-seq mESC enhancer starr_17322 Neighboring gene STARR-positive B cell enhancer ABC_E6488 Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124959611-124959720 Neighboring gene zinc finger protein 384 Neighboring gene STARR-positive B cell enhancer ABC_E1071 Neighboring gene STARR-seq mESC enhancer starr_17323 Neighboring gene STARR-positive B cell enhancer ABC_E6489 Neighboring gene inhibitor of growth family, member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pianp deficiency links GABA(B) receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior. Winkler M, et al. Mol Psychiatry, 2020 Nov. PMID 31511635, Free PMC Article
    2. Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages. Biswas S, et al. Biochem Biophys Res Commun, 2015 Sep 4. PMID 26188512
    3. Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein convertases precedes its plasma membrane localization. Evdokimov K, et al. Biochem Biophys Res Commun, 2013 Apr 26. PMID 23558288
    4. PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues. Kogure A, et al. Biochem Biophys Res Commun, 2011 Feb 18. PMID 21241660, Free PMC Article
    5. Complex formation of APP with GABA(B) receptors links axonal trafficking to amyloidogenic processing. Dinamarca MC, et al. Nat Commun, 2019 Mar 22. PMID 30902970, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pianp deficiency links GABAB receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior.
      Title: Pianp deficiency links GABA(B) receptor signaling and hippocampal and cerebellar neuronal cell composition to autism-like behavior.
    2. Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase.
      Title: Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase.
    3. demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilralpha is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation
      Title: Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages.
    4. Furin-like proprotein convertase-dependent processing precedes the plasma membrane localization of LEDA-1/PIANP that is required for functional receptor-ligand interactions in vitro and in vivo.
      Title: Proteolytic cleavage of LEDA-1/PIANP by furin-like proprotein convertases precedes its plasma membrane localization.
    5. These results suggest that PANP is involved in immune regulation as a ligand of the PILRalpha.
      Title: PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glutamate secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PILR alpha-associated neural protein
    Names
    PILR-associating neural protein
    brain protein 1
    paired immunoglobin-like type 2 receptor-associating neural protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145926.1 → NP_001139398.1  PILR alpha-associated neural protein precursor

      See identical proteins and their annotated locations for NP_001139398.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.
      Source sequence(s)
      AK082984, AK148352, BC065170
      Consensus CDS
      CCDS20540.1
      UniProtKB/Swiss-Prot
      Q3UFR0, Q6P1B3, Q71A40, Q8BHU8
      Related
      ENSMUSP00000124160.2, ENSMUST00000160704.8
      Conserved Domains (1) summary
      pfam15298
      Location:191 → 232
      AJAP1_PANP_C; AJAP1/PANP C-terminus

    2. NM_001145927.1 → NP_001139399.1  PILR alpha-associated neural protein precursor

      See identical proteins and their annotated locations for NP_001139399.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR exon, as compared to variant 1.
      Source sequence(s)
      AK082984, BC065170
      Consensus CDS
      CCDS20540.1
      UniProtKB/Swiss-Prot
      Q3UFR0, Q6P1B3, Q71A40, Q8BHU8
      Related
      ENSMUSP00000123940.2, ENSMUST00000162170.8
      Conserved Domains (1) summary
      pfam15298
      Location:191 → 232
      AJAP1_PANP_C; AJAP1/PANP C-terminus

    3. NM_175696.4 → NP_783627.2  PILR alpha-associated neural protein precursor

      See identical proteins and their annotated locations for NP_783627.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK082984, BB868634, BC065170
      Consensus CDS
      CCDS20540.1
      UniProtKB/Swiss-Prot
      Q3UFR0, Q6P1B3, Q71A40, Q8BHU8
      Related
      ENSMUSP00000032479.5, ENSMUST00000032479.11
      Conserved Domains (1) summary
      pfam15298
      Location:191 → 232
      AJAP1_PANP_C; AJAP1/PANP C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124973683..124980059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506234.4 → XP_006506297.1  PILR alpha-associated neural protein isoform X1

      See identical proteins and their annotated locations for XP_006506297.1

      UniProtKB/Swiss-Prot
      Q3UFR0, Q6P1B3, Q71A40, Q8BHU8
      Conserved Domains (1) summary
      pfam15298
      Location:191 → 232
      AJAP1_PANP_C; AJAP1/PANP C-terminus

    2. XM_006506236.4 → XP_006506299.1  PILR alpha-associated neural protein isoform X1

      See identical proteins and their annotated locations for XP_006506299.1

      UniProtKB/Swiss-Prot
      Q3UFR0, Q6P1B3, Q71A40, Q8BHU8
      Conserved Domains (1) summary
      pfam15298
      Location:191 → 232
      AJAP1_PANP_C; AJAP1/PANP C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1B3.1 GenPept UniProtKB/Swiss-Prot:Q6P1B3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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