Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif2ak1provided by RGD
Official Full Name: eukaryotic translation initiation factor 2 alpha kinase 1provided by RGD
Primary source: RGD:70883
See related: Ensembl:ENSRNOG00000001050 AllianceGenome:RGD:70883
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hri
Summary: Enables eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in several processes, including HRI-mediated signaling; negative regulation of hemoglobin biosynthetic process; and response to iron ion starvation. Predicted to act upstream of or within several processes, including macrophage differentiation; protoporphyrinogen IX metabolic process; and regulation of cellular macromolecule biosynthetic process. Predicted to be located in cytoplasm. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 357.3), Adrenal (RPKM 259.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (15824431..15858266, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (10710771..10744597, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (12749026..12782078, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BI293046 (e-PCR)
- UniSTS:245599

Pou5f1 (e-PCR), detects polymorphism
- UniSTS:498801

BI293383 (e-PCR)
- UniSTS:245628

RH128540 (e-PCR)
- UniSTS:211848

RH142857 (e-PCR)
- UniSTS:232104

BE120231 (e-PCR)
- UniSTS:247274

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in HRI-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in HRI-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in HRI-mediated signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in acute inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in integrated stress response signaling	ISO Inferred from Sequence Orthology more info
involved_in integrated stress response signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in macrophage differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level iron ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of hemoglobin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hemoglobin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hemoglobin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in protoporphyrinogen IX metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protoporphyrinogen IX metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of eIF2 alpha phosphorylation by heme	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of eIF2 alpha phosphorylation by heme	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of hemoglobin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational initiation by eIF2 alpha phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to iron ion starvation	IEA Inferred from Electronic Annotation more info
involved_in response to iron ion starvation	ISO Inferred from Sequence Orthology more info
involved_in response to iron ion starvation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 2-alpha kinase 1

Names: HCR; heme-controlled repressor; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; hemin-sensitive initiation factor 2-alpha kinase; hemin-sensitive initiation factor 2a kinase

NP_037355.2

EC 2.7.11.1

XP_038945063.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013223.2 → NP_037355.2 eukaryotic translation initiation factor 2-alpha kinase 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

Q63185, Q642C7

Related

ENSRNOP00000001392.4, ENSRNOT00000001392.9

Conserved Domains (1) summary

cd14049
Location:160 → 579

STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

15824431..15858266 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089135.2 → XP_038945063.1 eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K9K9

Related

ENSRNOP00000075036.1

Conserved Domains (1) summary

cd14049
Location:160 → 604

STKc_EIF2AK1_HRI; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase