Tspo translocator protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tspoprovided by RGD
Official Full Name: translocator proteinprovided by RGD
Primary source: RGD:2228
See related: Ensembl:ENSRNOG00000010549 AllianceGenome:RGD:2228
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MBR; Bzrp; Ptbzr; PTBZR02; RATPTBZR02
Summary: Enables androgen binding activity and benzodiazepine receptor activity. Involved in several processes, including cellular response to zinc ion; neurogenesis; and positive regulation of cell death. Located in mitochondrial outer membrane. Used to study cholesterol ester storage disease. Orthologous to human TSPO (translocator protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 1092.6), Lung (RPKM 365.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (116600214..116610461)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (114720188..114730450)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (124460358..124470610)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction.
Title: TSPO exacerbates acute cerebral ischemia/reperfusion injury by inducing autophagy dysfunction.
Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum.
Title: Reactive astrocytes mediate TSPO overexpression in response to sustained CNTF exposure in the rat striatum.
Translocator protein alleviates allodynia and improves Schwann cell function against diabetic peripheral neuropathy via activation of the Nrf2-dependent antioxidant system and promoting autophagy.
Title: Translocator protein alleviates allodynia and improves Schwann cell function against diabetic peripheral neuropathy via activation of the Nrf2-dependent antioxidant system and promoting autophagy.
TSPO Expression Modulatory Effect of Acetylcholinesterase Inhibitor in the Ischemic Stroke Rat Model.
Title: TSPO Expression Modulatory Effect of Acetylcholinesterase Inhibitor in the Ischemic Stroke Rat Model.
TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy.
Title: TSPO PET upregulation predicts epileptic phenotype at disease onset independently from chronic TSPO expression in a rat model of temporal lobe epilepsy.
The antidepressant and anxiolytic effect of GPER on translocator protein (TSPO) via protein kinase a (PKA) signaling in menopausal female rats.
Title: The antidepressant and anxiolytic effect of GPER on translocator protein (TSPO) via protein kinase a (PKA) signaling in menopausal female rats.
TSPO expression is up-regulated under anoxia/reoxygenation injury, and repression of TSPO improves the endurance of cardiomyocytes.
Title: Downregulation of TSPO expression inhibits oxidative stress and maintains mitochondrial homeostasis in cardiomyocytes subjected to anoxia/reoxygenation injury.
Study found no alcohol use disorder (AUD) group differences on [11C]PBR28 binding in our clinical study and no group differences in [11C]PBR28 uptake in the brain of alcohol-dependent versus -nondependent rats. However, when separately analyzing by TSPO genotype, found lower [11C]PBR28 binding in the brain of AUD patients than in healthy controls for medium-affinity binders only.
Title: Influence of alcoholism and cholesterol on TSPO binding in brain: PET [(11)C]PBR28 studies in humans and rodents.
These results suggest that the imidazole[1,2-a]pyridine-based radiotracer [(18)F]2 is a sensitive tool for noninvasively diagnosing myocarditis related to inflammation of the heart muscle by assessing abnormal TSPO expression.
Title: Assessment of TSPO in a Rat Experimental Autoimmune Myocarditis Model: A Comparison Study between [(18)F]Fluoromethyl-PBR28 and [(18)F]CB251.
Data suggest that protein (18kDa) (TSPO) may represent a novel therapeutic target for depression in type 2 diabetes mellitus (T2DM).
Title: The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus.

Submit: New GeneRIF Correction See all GeneRIFs (50)

General gene information

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Markers

D7Mit12 (e-PCR), detects polymorphism
- UniSTS:119396

Tspo (e-PCR), detects polymorphism
- UniSTS:528243

D7Wox20 (e-PCR)
- UniSTS:118134

d7arb10 (e-PCR)
- UniSTS:122281

RH94502 (e-PCR)
- UniSTS:119750

RH133285 (e-PCR)
- UniSTS:216568

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables androgen binding	IDA Inferred from Direct Assay more info	PubMed
enables benzodiazepine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adrenal gland development	IEP Inferred from Expression Pattern more info	PubMed
involved_in behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular hypotonic response	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in contact inhibition	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in glial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of corticosterone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in peripheral nervous system axon regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mitochondrial depolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of programmed necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to acetylcholine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to pain	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin B1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: translocator protein

Names: Benzodiazepin receptor (peripheral); PBR; PKBS; benzodiazepine receptor, peripheral; mitochondrial benzodiazepine receptor; peripheral-type benzodiazepine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012515.2 → NP_036647.1 translocator protein

See identical proteins and their annotated locations for NP_036647.1

Status: VALIDATED

Source sequence(s)

BQ194961, FM047408, J05122

UniProtKB/Swiss-Prot

P16257

UniProtKB/TrEMBL

A6HTA0

Related

ENSRNOP00000014089.1, ENSRNOT00000014089.5

Conserved Domains (1) summary

pfam03073
Location:12 → 155

TspO_MBR; TspO/MBR family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

116600214..116610461

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078393.2 → XP_038934321.1 translocator protein isoform X1

UniProtKB/Swiss-Prot

P16257

UniProtKB/TrEMBL

A6HTA0

Conserved Domains (1) summary

pfam03073
Location:12 → 155

TspO_MBR; TspO/MBR family
XM_039078394.2 → XP_038934322.1 translocator protein isoform X1

UniProtKB/Swiss-Prot

P16257

UniProtKB/TrEMBL

A6HTA0

Conserved Domains (1) summary

pfam03073
Location:12 → 155

TspO_MBR; TspO/MBR family