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    Xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble [ Mus musculus (house mouse) ]

    Gene ID: 170750, updated on 12-May-2024

    Summary

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    Official Symbol
    Xpnpep1provided by MGI
    Official Full Name
    X-prolyl aminopeptidase (aminopeptidase P) 1, solubleprovided by MGI
    Primary source
    MGI:MGI:2180003
    See related
    Ensembl:ENSMUSG00000025027 AllianceGenome:MGI:2180003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sAMP; D230045I08Rik
    Summary
    Predicted to enable manganese ion binding activity; metalloaminopeptidase activity; and protein homodimerization activity. Predicted to be involved in bradykinin catabolic process and proteolysis. Predicted to be located in cytosol. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 157.6), small intestine adult (RPKM 86.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Xpnpep1 in Genome Data Viewer
    Location:
    19 D2; 19 46.91 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (52919710..53027093, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (52931279..53038662, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41860 Neighboring gene STARR-seq mESC enhancer starr_46416 Neighboring gene STARR-seq mESC enhancer starr_46417 Neighboring gene STARR-seq mESC enhancer starr_46418 Neighboring gene STARR-seq mESC enhancer starr_46419 Neighboring gene STARR-seq mESC enhancer starr_46420 Neighboring gene expressed sequence AA387883 Neighboring gene predicted gene, 41861 Neighboring gene STARR-positive B cell enhancer ABC_E7671 Neighboring gene STARR-seq mESC enhancer starr_46426 Neighboring gene STARR-seq mESC enhancer starr_46431 Neighboring gene microRNA 6407 Neighboring gene STARR-seq mESC enhancer starr_46433 Neighboring gene RIKEN cDNA 1700054A03 gene Neighboring gene predicted gene, 54048 Neighboring gene predicted gene, 30234

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency. Yoon SH, et al. Sci Rep, 2021 Jan 13. PMID 33441619, Free PMC Article
    2. Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1. Yoon SH, et al. Biochem Biophys Res Commun, 2012 Dec 14. PMID 23131567
    3. Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Clee SM, et al. Nat Genet, 2006 Jun. PMID 16682971
    4. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency.
      Title: Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency.
    2. These results suggest an essential role for APP1-mediated peptide metabolism in body and brain development, and indicate a strong causal link between APP1 deficiency and peptiduria.
      Title: Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bradykinin catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    xaa-Pro aminopeptidase 1
    Names
    X-Pro aminopeptidase 1
    aminoacylproline aminopeptidase
    cytosolic aminopeptidase P
    NP_001361763.1
    NP_573479.3
    XP_011245460.1
    XP_011245461.1
    XP_017173564.1
    XP_030106621.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374834.1 → NP_001361763.1  xaa-Pro aminopeptidase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163221
      Consensus CDS
      CCDS89415.1
      UniProtKB/Swiss-Prot
      Q6P1B1, Q91Y37
      UniProtKB/TrEMBL
      Q3TL27, Q3UKF5
      Conserved Domains (4) summary
      cd01085
      Location:329 → 551
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:557 → 618
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:157 → 326
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:10 → 154
      Creatinase_N; Creatinase/Prolidase N-terminal domain

    2. NM_133216.4 → NP_573479.3  xaa-Pro aminopeptidase 1 isoform 1

      See identical proteins and their annotated locations for NP_573479.3

      Status: VALIDATED

      Source sequence(s)
      AC163221
      Consensus CDS
      CCDS29899.2
      UniProtKB/TrEMBL
      Q3UE92, S4R1I3
      Related
      ENSMUSP00000138250.2, ENSMUST00000183108.8
      Conserved Domains (4) summary
      cd01085
      Location:372 → 594
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:600 → 661
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:200 → 369
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:53 → 197
      Creatinase_N; Creatinase/Prolidase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      52919710..53027093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247158.3 → XP_011245460.1  xaa-Pro aminopeptidase 1 isoform X1

      UniProtKB/TrEMBL
      S4R1I3
      Conserved Domains (4) summary
      cd01085
      Location:372 → 594
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:600 → 624
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:200 → 369
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:53 → 197
      Creatinase_N; Creatinase/Prolidase N-terminal domain

    2. XM_030250761.2 → XP_030106621.1  xaa-Pro aminopeptidase 1 isoform X3

      UniProtKB/TrEMBL
      A0A494BBG8, Q3TL27
      Related
      ENSMUSP00000158501.2, ENSMUST00000236008.2
      Conserved Domains (4) summary
      cd01085
      Location:329 → 551
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:557 → 581
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:157 → 326
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:10 → 154
      Creatinase_N; Creatinase/Prolidase N-terminal domain

    3. XM_011247159.2 → XP_011245461.1  xaa-Pro aminopeptidase 1 isoform X2

      See identical proteins and their annotated locations for XP_011245461.1

      UniProtKB/Swiss-Prot
      Q6P1B1, Q91Y37
      UniProtKB/TrEMBL
      Q3TL27, Q3UKF5
      Related
      ENSMUSP00000158390.2, ENSMUST00000237294.2
      Conserved Domains (4) summary
      cd01085
      Location:329 → 551
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:557 → 618
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:157 → 326
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:10 → 154
      Creatinase_N; Creatinase/Prolidase N-terminal domain

    4. XM_017318075.3 → XP_017173564.1  xaa-Pro aminopeptidase 1 isoform X4

      UniProtKB/TrEMBL
      Q3TL27
      Related
      ENSMUST00000182877.8
      Conserved Domains (3) summary
      cd01085
      Location:258 → 480
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:486 → 547
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:86 → 255
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1B1.1 GenPept UniProtKB/Swiss-Prot:Q6P1B1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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