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    Pigc phosphatidylinositol glycan anchor biosynthesis, class C [ Mus musculus (house mouse) ]

    Gene ID: 67292, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Pigcprovided by MGI
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Cprovided by MGI
    Primary source
    MGI:MGI:1914542
    See related
    Ensembl:ENSMUSG00000026698 AllianceGenome:MGI:1914542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3110030E07Rik
    Summary
    Predicted to enable phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Is expressed in eye; facial bone primordium; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human PIGC (phosphatidylinositol glycan anchor biosynthesis class C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 10.1), limb E14.5 (RPKM 9.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pigc in Genome Data Viewer
    Location:
    1 H2.1; 1 69.95 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (161796757..161801029)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161969188..161973460)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10050 Neighboring gene cyclin-dependent kinase 7 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2578 Neighboring gene SUN domain containing ossification factor Neighboring gene STARR-positive B cell enhancer ABC_E7766 Neighboring gene STARR-seq mESC enhancer starr_02830 Neighboring gene RIKEN cDNA 4930558K02 gene Neighboring gene predicted gene, 31925 Neighboring gene STARR-positive B cell enhancer ABC_E4367 Neighboring gene STARR-positive B cell enhancer mm9_chr1:163906574-163906875 Neighboring gene STARR-seq mESC enhancer starr_02833 Neighboring gene RIKEN cDNA 2810442N19 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:163930050-163930233 Neighboring gene dynamin 3 Neighboring gene STARR-seq mESC enhancer starr_02834 Neighboring gene VISTA enhancer mm712 Neighboring gene STARR-seq mESC enhancer starr_02835 Neighboring gene STARR-seq mESC enhancer starr_02836 Neighboring gene microRNA 199a-2 Neighboring gene dynamin 3, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase subunit C
    Names
    PIG-C
    phosphatidylinositol-glycan biosynthesis class C protein
    NP_001034134.1
    NP_080354.1
    XP_006497022.1
    XP_030098184.1
    XP_036009010.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039045.1 → NP_001034134.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

      See identical proteins and their annotated locations for NP_001034134.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK152660, CAAA01056494, CJ171161
      Consensus CDS
      CCDS15419.1
      UniProtKB/Swiss-Prot
      Q3U7H3, Q9CXR4
      UniProtKB/TrEMBL
      Q3TDK1, Q3U1G9
      Related
      ENSMUSP00000107221.3, ENSMUST00000111594.3
      Conserved Domains (1) summary
      pfam06432
      Location:14 → 284
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

    2. NM_026078.2 → NP_080354.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C

      See identical proteins and their annotated locations for NP_080354.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK014096, CAAA01056494, CJ171161
      Consensus CDS
      CCDS15419.1
      UniProtKB/Swiss-Prot
      Q3U7H3, Q9CXR4
      UniProtKB/TrEMBL
      Q3TDK1, Q3U1G9
      Related
      ENSMUSP00000028021.7, ENSMUST00000028021.7
      Conserved Domains (1) summary
      pfam06432
      Location:14 → 284
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      161796757..161801029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496959.3 → XP_006497022.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

      See identical proteins and their annotated locations for XP_006497022.1

      UniProtKB/Swiss-Prot
      Q3U7H3, Q9CXR4
      UniProtKB/TrEMBL
      Q3TDK1, Q3U1G9
      Conserved Domains (1) summary
      pfam06432
      Location:14 → 284
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

    2. XM_030242324.2 → XP_030098184.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

      UniProtKB/Swiss-Prot
      Q3U7H3, Q9CXR4
      UniProtKB/TrEMBL
      Q3TDK1, Q3U1G9
      Conserved Domains (1) summary
      pfam06432
      Location:14 → 284
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase

    3. XM_036153117.1 → XP_036009010.1  phosphatidylinositol N-acetylglucosaminyltransferase subunit C isoform X1

      UniProtKB/Swiss-Prot
      Q3U7H3, Q9CXR4
      UniProtKB/TrEMBL
      Q3TDK1, Q3U1G9
      Related
      ENSMUSP00000141646.2, ENSMUST00000193784.2
      Conserved Domains (1) summary
      pfam06432
      Location:14 → 284
      GPI2; Phosphatidylinositol N-acetylglucosaminyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXR4.1 GenPept UniProtKB/Swiss-Prot:Q9CXR4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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