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    Map3k14 mitogen-activated protein kinase kinase kinase 14 [ Mus musculus (house mouse) ]

    Gene ID: 53859, updated on 28-May-2024

    Summary

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    Official Symbol
    Map3k14provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 14provided by MGI
    Primary source
    MGI:MGI:1858204
    See related
    Ensembl:ENSMUSG00000020941 AllianceGenome:MGI:1858204
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nik; aly
    Summary
    Enables NF-kappaB-inducing kinase activity. Involved in I-kappaB kinase/NF-kappaB signaling and immune response. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; sensory organ; and skeleton. Used to study Sjogren's syndrome and primary biliary cholangitis. Orthologous to human MAP3K14 (mitogen-activated protein kinase kinase kinase 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 11.8), thymus adult (RPKM 8.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map3k14 in Genome Data Viewer
    Location:
    11 E1; 11 66.8 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103110590..103158227, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103219764..103267401, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 15 Neighboring gene spermatogenesis associated 32 Neighboring gene predicted gene, 51920 Neighboring gene predicted gene, 34823 Neighboring gene STARR-positive B cell enhancer ABC_E10718 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:103128947-103129269 Neighboring gene STARR-seq mESC enhancer starr_30841 Neighboring gene STARR-seq mESC enhancer starr_30842 Neighboring gene STARR-positive B cell enhancer ABC_E3026 Neighboring gene Rho GTPase activating protein 27 Neighboring gene Rho GTPase activating protein 27, opposite strand 3 Neighboring gene STARR-positive B cell enhancer ABC_E8459 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 1 Neighboring gene STARR-seq mESC enhancer starr_30848 Neighboring gene STARR-positive B cell enhancer ABC_E9376

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NF-κB-inducing kinase maintains mitochondrial efficiency and systemic metabolic homeostasis. Pflug KM, et al. Biochim Biophys Acta Mol Basis Dis, 2023 Jun. PMID 36878304
    2. Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia. Lu YJ, et al. Aging (Albany NY), 2020 Apr 24. PMID 32330120, Free PMC Article
    3. SMAC mimetics promote NIK-dependent inhibition of CD4(+) T(H)17 cell differentiation. Rizk J, et al. Sci Signal, 2019 Aug 27. PMID 31455723
    4. Islet α-cell Inflammation Induced By NF-κB inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice. Li X, et al. Theranostics, 2018. PMID 30613274, Free PMC Article
    5. Noncanonical NF-κB signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis. Eden K, et al. Dis Model Mech, 2017 Dec 19. PMID 29259025, Free PMC Article

    See all (203) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High expression of NF-kappaB inducing kinase in the bulge region of hair follicle induces tumor.
      Title: High expression of NF-κB inducing kinase in the bulge region of hair follicle induces tumor.
    2. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
      Title: EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
    3. NF-kappaB-inducing kinase maintains mitochondrial efficiency and systemic metabolic homeostasis.
      Title: NF-κB-inducing kinase maintains mitochondrial efficiency and systemic metabolic homeostasis.
    4. NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
      Title: NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
    5. Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-kappaB-inducing kinase in mice.
      Title: Hepatic neddylation deficiency triggers fatal liver injury via inducing NF-κB-inducing kinase in mice.
    6. Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
      Title: Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice.
    7. Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of Treg development.
      Title: Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of T(reg) development.
    8. Constitutive activation of NF-kappaB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
      Title: Constitutive activation of NF-κB inducing kinase (NIK) in the mesenchymal lineage using Osterix (Sp7)- or Fibroblast-specific protein 1 (S100a4)-Cre drives spontaneous soft tissue sarcoma.
    9. NF-kappaB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
      Title: NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
    10. NIK links inflammation to hepatic steatosis by suppressing PPARalpha in alcoholic liver disease.
      Title: NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease.
    Submit: New GeneRIF Correction See all GeneRIFs (70)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3) 
    • Spontaneous (1)  1 citation
    • Targeted (7)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 14
    Names
    NF kappa B-inducing kinase
    NF-kappa-beta-inducing kinase
    Nfkb inducing kinase
    alymphoplasia
    serine/threonine-protein kinase NIK
    NP_058592.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016896.3 → NP_058592.1  mitogen-activated protein kinase kinase kinase 14

      See identical proteins and their annotated locations for NP_058592.1

      Status: VALIDATED

      Source sequence(s)
      AK036200
      Consensus CDS
      CCDS25516.1
      UniProtKB/Swiss-Prot
      Q9WUL6
      UniProtKB/TrEMBL
      Q544K4
      Related
      ENSMUSP00000021324.3, ENSMUST00000021324.3
      Conserved Domains (2) summary
      smart00220
      Location:408 → 667
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13991
      Location:395 → 662
      STKc_NIK; Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      103110590..103158227 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUL6.1 GenPept UniProtKB/Swiss-Prot:Q9WUL6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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