U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Card6 caspase recruitment domain family, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 239319, updated on 9-May-2024

    Summary

    Official Symbol
    Card6provided by MGI
    Official Full Name
    caspase recruitment domain family, member 6provided by MGI
    Primary source
    MGI:MGI:3032959
    See related
    Ensembl:ENSMUSG00000041849 AllianceGenome:MGI:3032959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D730008L15
    Summary
    Predicted to act upstream of or within regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in cytoplasm. Is expressed in heart ventricle; lung; upper arm muscle; upper leg muscle; and vertebral axis musculature. Orthologous to human CARD6 (caspase recruitment domain family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 1.0), testis adult (RPKM 0.6) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Card6 in Genome Data Viewer
    Location:
    15 A1; 15 1.99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (5126402..5146762, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (5096920..5116562, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene complement component 7 Neighboring gene predicted gene, 25652 Neighboring gene caspase recruitment domain family, member 6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8583 Neighboring gene STARR-positive B cell enhancer ABC_E1171 Neighboring gene small nucleolar RNA, C/D box 72 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d pseudogene Neighboring gene ribosomal protein L37

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    General protein information

    Preferred Names
    caspase recruitment domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163138.1NP_001156610.1  caspase recruitment domain-containing protein 6

      See identical proteins and their annotated locations for NP_001156610.1

      Status: VALIDATED

      Source sequence(s)
      AC131919
      Consensus CDS
      CCDS49573.1
      UniProtKB/TrEMBL
      E9PWH2, Q8BWE0
      Related
      ENSMUSP00000112833.3, ENSMUST00000118365.3
      Conserved Domains (2) summary
      PHA03247
      Location:7891166
      PHA03247; large tegument protein UL36; Provisional
      pfam00619
      Location:988
      CARD; Caspase recruitment domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      5126402..5146762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519987.5XP_006520050.2  caspase recruitment domain-containing protein 6 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:9391316
      PHA03247; large tegument protein UL36; Provisional
      cd01671
      Location:161229
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    2. XM_030248533.1XP_030104393.1  caspase recruitment domain-containing protein 6 isoform X2

      UniProtKB/TrEMBL
      E9PWH2, Q8BWE0
      Conserved Domains (2) summary
      PHA03247
      Location:7891166
      PHA03247; large tegument protein UL36; Provisional
      pfam00619
      Location:988
      CARD; Caspase recruitment domain