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    Aox4 aldehyde oxidase 4 [ Mus musculus (house mouse) ]

    Gene ID: 71872, updated on 12-May-2024

    Summary

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    Official Symbol
    Aox4provided by MGI
    Official Full Name
    aldehyde oxidase 4provided by MGI
    Primary source
    MGI:MGI:1919122
    See related
    Ensembl:ENSMUSG00000038242 AllianceGenome:MGI:1919122
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aoh2; 2310003G12Rik
    Summary
    Predicted to enable aldehyde oxidase activity; electron transfer activity; and molybdenum ion binding activity. Predicted to be located in cytoplasm. Is expressed in anterior naris and external naris. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 1.8), testis adult (RPKM 0.4) and 10 other tissues See more
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    Genomic context

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    See Aox4 in Genome Data Viewer
    Location:
    1 C1.3; 1 28.97 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58249556..58307759)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58210397..58268600)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01005 Neighboring gene predicted gene, 39643 Neighboring gene aldehyde oxidase 3 Neighboring gene predicted gene, 24548 Neighboring gene predicted gene 15759 Neighboring gene aldehyde oxidase 2 Neighboring gene ribosomal protein S27 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity. Terao M, et al. Sci Rep, 2016 Jul 26. PMID 27456060, Free PMC Article
    2. Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse. Terao M, et al. Mol Cell Biol, 2009 Jan. PMID 18981221, Free PMC Article
    3. Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase. Terao M, et al. J Biol Chem, 2000 Sep 29. PMID 10893244
    4. Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases. Cerqueira NM, et al. J Biol Inorg Chem, 2015 Mar. PMID 25287365
    5. The aldehyde oxidase gene cluster in mice and rats. Aldehyde oxidase homologue 3, a novel member of the molybdo-flavoenzyme family with selective expression in the olfactory mucosa. Kurosaki M, et al. J Biol Chem, 2004 Nov 26. PMID 15383531

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of the Aox4 gene causes perturbations in diurnal rhythms, fat deposition and locomotor activity.
      Title: Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity.
    2. Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
      Title: Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases.
    3. data indicate a significant role of AOH2 in the local synthesis and biodisposition of endogenous retinoids in the Harderian gland and skin
      Title: Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144189, MGC144190

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde oxidase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables electron transfer activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdenum ion binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde oxidase 4
    Names
    aldehyde oxidase homolog 2
    aldehyde oxidase structural homolog 2
    azaheterocycle hydroxylase 4
    retinal oxidase
    NP_076120.2
    XP_006496350.1
    XP_036009585.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023631.2 → NP_076120.2  aldehyde oxidase 4

      See identical proteins and their annotated locations for NP_076120.2

      Status: VALIDATED

      Source sequence(s)
      AC025116, AI414378, AK158427
      Consensus CDS
      CCDS14970.1
      UniProtKB/Swiss-Prot
      Q3TYQ9, Q8VI17
      UniProtKB/TrEMBL
      Q148T8
      Related
      ENSMUSP00000048929.6, ENSMUST00000040442.6
      Conserved Domains (7) summary
      TIGR02969
      Location:9 → 1335
      mam_aldehyde_ox; aldehyde oxidase
      smart01008
      Location:596 → 699
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      pfam00111
      Location:12 → 82
      Fer2; 2Fe-2S iron-sulfur cluster binding domain
      pfam00941
      Location:240 → 420
      FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
      pfam01799
      Location:91 → 162
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:713 → 1243
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:431 → 532
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58249556..58307759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153692.1 → XP_036009585.1  aldehyde oxidase 4 isoform X1

      UniProtKB/TrEMBL
      Q148T8
      Conserved Domains (1) summary
      TIGR02969
      Location:2 → 1160
      mam_aldehyde_ox; aldehyde oxidase

    2. XM_006496287.2 → XP_006496350.1  aldehyde oxidase 4 isoform X2

      UniProtKB/TrEMBL
      Q148T8
      Conserved Domains (1) summary
      TIGR02969
      Location:9 → 1119
      mam_aldehyde_ox; aldehyde oxidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TYQ9.1 GenPept UniProtKB/Swiss-Prot:Q3TYQ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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