Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hsd17b6provided by RGD
Full Name: hydroxysteroid (17-beta) dehydrogenase 6provided by RGD
Primary source: RGD:708343
See related: Ensembl:ENSRNOG00000002597 AllianceGenome:RGD:708343
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hsd17b9
Summary: Enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in brexanolone catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Orthologous to human HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1181.4) See more
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Genomic context

Location:: 7q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (831407..850950, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (422466..442008, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (2412370..2431249, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 5alpha-androstane-3beta,17beta-diol dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	IDA Inferred from Direct Assay more info	PubMed
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables testosterone 17-beta-dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables testosterone dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase (NAD+) activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in androgen metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in brexanolone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in brexanolone catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 17-beta-hydroxysteroid dehydrogenase type 6

Names: 17-beta-HSD 6; 17-beta-HSD6; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; hydroxysteroid (17-beta) dehydrogenase 9; hydroxysteroid 17-beta dehydrogenase 6-like; oxidative 17 beta hydroxysteroid dehydrogenase type 6; oxidative 3-alpha hydroxysteroid dehydrogenase

NP_775427.2

EC 1.1.1.105

EC 1.1.1.209

EC 1.1.1.239

EC 1.1.1.53

EC 1.1.1.62

XP_017450177.2

EC 1.1.1.105

EC 1.1.1.209

EC 1.1.1.239

EC 1.1.1.53

EC 1.1.1.62

XP_063119152.1

EC 1.1.1.105

EC 1.1.1.209

EC 1.1.1.239

EC 1.1.1.53

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173305.2 → NP_775427.2 17-beta-hydroxysteroid dehydrogenase type 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A8I6AMC0

Related

ENSRNOP00000094822.1, ENSRNOT00000103179.1

Conserved Domains (1) summary

cl21454
Location:40 → 316

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

831407..850950 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594688.3 → XP_017450177.2 17-beta-hydroxysteroid dehydrogenase type 6 isoform X2

UniProtKB/Swiss-Prot

O54753, Q5M8C8

UniProtKB/TrEMBL

A0A8I6AMC0

Conserved Domains (1) summary

cl21454
Location:30 → 306

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
XM_063263082.1 → XP_063119152.1 17-beta-hydroxysteroid dehydrogenase type 6 isoform X1

UniProtKB/TrEMBL

F1LYR5