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    Eif4a1 eukaryotic translation initiation factor 4A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287436, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Eif4a1provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4A1provided by RGD
    Primary source
    RGD:735141
    See related
    Ensembl:ENSRNOG00000030628 AllianceGenome:RGD:735141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable double-stranded RNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in cytoplasm. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 1843.3), Spleen (RPKM 1273.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif4a1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54883093..54888602, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54384345..54389855, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56271257..56276764, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 15 Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene Cd68 molecule Neighboring gene small nucleolar RNA SNORA48 Neighboring gene small nucleolar RNA, H/ACA box 67 Neighboring gene small nucleolar RNA, C/D box 10 Neighboring gene eukaryotic translation initiation factor 4A1 like Neighboring gene SUMO specific peptidase 3 Neighboring gene TNF superfamily member 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI. Hashimoto K, et al. PLoS One, 2010 Nov 8. PMID 21151481, Free PMC Article
    2. Selective translational control and nonspecific posttranscriptional regulation of ribosomal protein gene expression during development and regeneration of rat liver. Aloni R, et al. Mol Cell Biol, 1992 May. PMID 1373810, Free PMC Article
    3. The diverse roles of the eIF4A family: you are the company you keep. Lu WT, et al. Biochem Soc Trans, 2014 Feb. PMID 24450646
    4. Cloning of eukaryotic protein synthesis initiation factor genes: isolation and characterization of cDNA clones encoding factor eIF-4A. Nielsen PJ, et al. Nucleic Acids Res, 1985 Oct 11. PMID 3840589, Free PMC Article
    5. mRNA helicases: the tacticians of translational control. Parsyan A, et al. Nat Rev Mol Cell Biol, 2011 Apr. PMID 21427765

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings suggest that eIF4AI might play a role in the novel mechanism of minocycline.
      Title: A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic initiation factor 4A-I
    Names
    eukaryotic translation initiation factor 4A
    NP_955404.1
    XP_006246686.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199372.3 → NP_955404.1  eukaryotic initiation factor 4A-I

      See identical proteins and their annotated locations for NP_955404.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A0E5, A6HFS9, Q6P3V8
      Related
      ENSRNOP00000086003.1, ENSRNOT00000100375.1
      Conserved Domains (1) summary
      PTZ00424
      Location:20 → 406
      PTZ00424; helicase 45; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54883093..54888602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246624.5 → XP_006246686.1  eukaryotic initiation factor 4A-I isoform X1

      UniProtKB/TrEMBL
      A6HFS9, F7F7A6
      Related
      ENSRNOP00000049419.2
      Conserved Domains (3) summary
      PTZ00424
      Location:25 → 411
      PTZ00424; helicase 45; Provisional
      cd00079
      Location:251 → 366
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:39 → 240
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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