Mtmr3 myotubularin related protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtmr3provided by MGI
Official Full Name: myotubularin related protein 3provided by MGI
Primary source: MGI:MGI:1921552
See related: Ensembl:ENSMUSG00000034354 AllianceGenome:MGI:1921552
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZFYVE10; FYVE-DSP1; mKIAA0371; 1700092A20Rik
Summary: Predicted to enable phosphatase activity and protein phosphatase binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; phosphatidylinositol metabolic process; and regulation of phosphatidylinositol dephosphorylation. Predicted to act upstream of or within lipid metabolic process. Predicted to be extrinsic component of membrane. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTMR3 (myotubularin related protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 14.9), thymus adult (RPKM 14.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 2.94 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (4430867..4544863, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (4480867..4594863, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.
Title: MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.
these results suggest that MTMR3 and MTMR4 regulate the production of PtdIns3P, which plays a critical role in suppressing DNA-mediated innate immune responses via modulating STING trafficking.
Title: PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW557713 (e-PCR)
- UniSTS:185861

BM386970 (e-PCR)
- UniSTS:261658

RH136017 (e-PCR)
- UniSTS:210013

D11Mit72 (e-PCR), detects polymorphism
- UniSTS:126619

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 5-phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myotubularin-related protein 3

Names: phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase

NP_001360826.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

NP_083136.2

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_006514908.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_006514909.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_006514911.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_036012929.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_036012930.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

XP_036012931.1

EC 3.1.3.48

EC 3.1.3.64

EC 3.1.3.95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001373897.1 → NP_001360826.1 myotubularin-related protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

AL606521, AL645910

UniProtKB/Swiss-Prot

Q5NCA4, Q8K296

UniProtKB/TrEMBL

R4GML8

Related

ENSMUSP00000122422.3, ENSMUST00000123506.9

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1113 → 1173

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
NM_028860.2 → NP_083136.2 myotubularin-related protein 3 isoform 2

See identical proteins and their annotated locations for NP_083136.2

Status: VALIDATED

Source sequence(s)

AK122261, AK141138, AW046647, CB249296, CB527330, CF532066, CJ048010, CV557784, CX566279

Consensus CDS

CCDS48744.1

UniProtKB/TrEMBL

B1ATD5, Q66I45

Related

ENSMUSP00000105569.4, ENSMUST00000109943.10

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1076 → 1136

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

4430867..4544863 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157038.1 → XP_036012931.1 myotubularin-related protein 3 isoform X4

UniProtKB/TrEMBL

M0QW74

Related

ENSMUSP00000137687.2, ENSMUST00000130716.8

Conserved Domains (2) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_006514848.4 → XP_006514911.1 myotubularin-related protein 3 isoform X2

UniProtKB/TrEMBL

B1ATD4

Related

ENSMUSP00000116315.3, ENSMUST00000128256.3

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1076 → 1145

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_006514845.4 → XP_006514908.1 myotubularin-related protein 3 isoform X1

See identical proteins and their annotated locations for XP_006514908.1

UniProtKB/TrEMBL

R4GML8

Related

ENSMUSP00000159982.1, ENSMUST00000249885.1

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1113 → 1182

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_006514846.4 → XP_006514909.1 myotubularin-related protein 3 isoform X1

See identical proteins and their annotated locations for XP_006514909.1

UniProtKB/TrEMBL

R4GML8

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1113 → 1182

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_036157036.1 → XP_036012929.1 myotubularin-related protein 3 isoform X1

UniProtKB/TrEMBL

R4GML8

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1113 → 1182

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3
XM_036157037.1 → XP_036012930.1 myotubularin-related protein 3 isoform X3

UniProtKB/TrEMBL

B1ATD5, Q66I45

Conserved Domains (3) summary

cd13341
Location:23 → 116

PH-GRAM_MTMR3; Myotubularian (MTM) related 3 protein (MTMR3) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd15732
Location:1076 → 1136

FYVE_MTMR3; FYVE domain found in myotubularin-related protein 3 (MTMR3) and similar proteins

cd14586
Location:169 → 485

PTP-MTMR3; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 3