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    Commd4 COMM domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363068, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Commd4provided by RGD
    Official Full Name
    COMM domain containing 4provided by RGD
    Primary source
    RGD:1306104
    See related
    Ensembl:ENSRNOG00000018671 AllianceGenome:RGD:1306104
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Orthologous to human COMMD4 (COMM domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 226.5), Kidney (RPKM 187.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Commd4 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66462188..66465700, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57566236..57569701, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61833340..61836872, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene nei-like DNA glycosylase 1 Neighboring gene voltage-dependent anion channel 2, pseudogene 2 Neighboring gene uncharacterized LOC103693103

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COMM domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108762.1 → NP_001102232.1  COMM domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001102232.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A0A0G2K6N9, A6J4T1, D4A2Q7
      Related
      ENSRNOP00000061735.1, ENSRNOT00000064903.2
      Conserved Domains (1) summary
      cl06336
      Location:26 → 176
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

    2. NM_001401178.1 → NP_001388107.1  COMM domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J4T2
      Related
      ENSRNOP00000073885.2, ENSRNOT00000084009.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      66462188..66465700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265755.1 → XP_063121825.1  COMM domain-containing protein 4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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