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    Hagh hydroxyacyl glutathione hydrolase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24439, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Haghprovided by RGD
    Official Full Name
    hydroxyacyl glutathione hydrolaseprovided by RGD
    Primary source
    RGD:2779
    See related
    Ensembl:ENSRNOG00000014743 AllianceGenome:RGD:2779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Glo2; RSP29
    Summary
    Enables hydroxyacylglutathione hydrolase activity. Involved in carbohydrate metabolic process and glutathione metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human HAGH (hydroxyacylglutathione hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 640.0), Liver (RPKM 619.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hagh in Genome Data Viewer
    Location:
    10q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14379400..14394046)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13874883..13889527)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14215913..14230506)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 6 Neighboring gene meiosis specific with OB-fold Neighboring gene transfer RNA proline (anticodon AGG) 67 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene NUBP iron-sulfur cluster assembly factor 2 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and characterization of a rat spermatogenesis-associated protein RSP29. Ji X, et al. Biochem Biophys Res Commun, 1997 Dec 29. PMID 9434774
    2. Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus. Skapare E, et al. J Physiol Sci, 2012 Nov. PMID 22893478, Free PMC Article
    3. The Human hydroxyacylglutathione hydrolase (HAGH) gene encodes both cytosolic and mitochondrial forms of glyoxalase II. Cordell PA, et al. J Biol Chem, 2004 Jul 2. PMID 15117945
    4. Changes in concentrations of methylglyoxal, D-lactate and glyoxalase activities in liver and plasma of rats fed a 3'-methyl-4-dimethylaminoazobenzene-rich diet. Kawase M, et al. Res Exp Med (Berl), 1996. PMID 8903102
    5. Contents of D-lactate and its related metabolites as well as enzyme activities in the liver, muscle and blood plasma of aging rats. Kawase M, et al. Mech Ageing Dev, 1995 Sep 29. PMID 8719777

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Changes in glyoxalase 1 and glyoxalase 2 activities and the development of diabetic complications in experimental animal models of obesity.
      Title: Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydroxyacylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxyacylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyacylglutathione hydrolase, mitochondrial
    Names
    glx II
    glyoxalase II
    round spermatid protein RSP29
    NP_203500.2
    XP_006245961.1
    XP_006245962.1
    XP_063124468.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429891.1 → NP_001416820.1  hydroxyacylglutathione hydrolase, mitochondrial isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O35952, Q4V8M8

    2. NM_001429892.1 → NP_001416821.1  hydroxyacylglutathione hydrolase, mitochondrial isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O35952, Q4V8M8

    3. NM_001429893.1 → NP_001416822.1  hydroxyacylglutathione hydrolase, mitochondrial isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O35952, Q4V8M8

    4. NM_033349.3 → NP_203500.2  hydroxyacylglutathione hydrolase, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_203500.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O35952, Q4V8M8
      UniProtKB/TrEMBL
      A6HCX7
      Related
      ENSRNOP00000020192.4, ENSRNOT00000020192.6
      Conserved Domains (3) summary
      PLN02469
      Location:50 → 305
      PLN02469; hydroxyacylglutathione hydrolase
      pfam16123
      Location:223 → 303
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
      cd07723
      Location:55 → 222
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14379400..14394046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245900.4 → XP_006245962.1  hydroxyacylglutathione hydrolase, mitochondrial isoform X1

      Conserved Domains (1) summary
      PLN02469
      Location:2 → 257
      PLN02469; hydroxyacylglutathione hydrolase

    2. XM_006245899.4 → XP_006245961.1  hydroxyacylglutathione hydrolase, mitochondrial isoform X1

      Conserved Domains (1) summary
      PLN02469
      Location:2 → 257
      PLN02469; hydroxyacylglutathione hydrolase

    3. XM_063268398.1 → XP_063124468.1  hydroxyacylglutathione hydrolase, mitochondrial isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35952.2 GenPept UniProtKB/Swiss-Prot:O35952

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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