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    Smim3 small integral membrane protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286910, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Smim3provided by RGD
    Official Full Name
    small integral membrane protein 3provided by RGD
    Primary source
    RGD:628864
    See related
    Ensembl:ENSRNOG00000019536 AllianceGenome:RGD:628864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nid67
    Summary
    Predicted to enable identical protein binding activity. Predicted to be integral component of membrane. Orthologous to human SMIM3 (small integral membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 132.0), Adrenal (RPKM 114.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Smim3 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (56200458..56252778, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (53930019..53982339, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (55744809..55797186, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene interferon-gamma-inducible GTPase 2 like 2 Neighboring gene interferon-gamma-inducible GTPase 2 like, pseudogene 1 Neighboring gene dynactin subunit 4 Neighboring gene RNA binding motif protein 22 Neighboring gene myozenin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells. Vician L, et al. J Neurosci Res, 2001 Apr 15. PMID 11288140
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small integral membrane protein 3
    Names
    NGF-induced differentiation clone 67 protein
    putative small membrane protein NID67
    small membrane protein NID67

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173126.3 → NP_775149.1  small integral membrane protein 3

      See identical proteins and their annotated locations for NP_775149.1

      Status: VALIDATED

      Source sequence(s)
      AF313411, BC070515, EV780394
      UniProtKB/Swiss-Prot
      Q99PE6
      UniProtKB/TrEMBL
      A6IXB1
      Related
      ENSRNOP00000026426.3, ENSRNOT00000026426.6
      Conserved Domains (1) summary
      pfam17307
      Location:1 → 60
      Smim3; Small integral membrane protein 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      56200458..56252778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600864.3 → XP_017456353.1  small integral membrane protein 3 isoform X6

      UniProtKB/Swiss-Prot
      Q99PE6
      UniProtKB/TrEMBL
      A6IXB1
      Conserved Domains (1) summary
      pfam17307
      Location:1 → 60
      Smim3; Small integral membrane protein 3

    2. XM_039096614.2 → XP_038952542.1  small integral membrane protein 3 isoform X6

      UniProtKB/Swiss-Prot
      Q99PE6
      UniProtKB/TrEMBL
      A6IXB1
      Conserved Domains (1) summary
      pfam17307
      Location:1 → 60
      Smim3; Small integral membrane protein 3

    3. XM_039096609.2 → XP_038952537.1  small integral membrane protein 3 isoform X1

      Conserved Domains (1) summary
      pfam17307
      Location:57 → 116
      Smim3; Small integral membrane protein 3

    4. XM_039096613.2 → XP_038952541.1  small integral membrane protein 3 isoform X6

      UniProtKB/Swiss-Prot
      Q99PE6
      UniProtKB/TrEMBL
      A6IXB1
      Conserved Domains (1) summary
      pfam17307
      Location:1 → 60
      Smim3; Small integral membrane protein 3

    5. XM_063277153.1 → XP_063133223.1  small integral membrane protein 3 isoform X6

      UniProtKB/Swiss-Prot
      Q99PE6
      UniProtKB/TrEMBL
      A6IXB1

    6. XM_063277149.1 → XP_063133219.1  small integral membrane protein 3 isoform X3

    7. XM_006254769.4 → XP_006254831.1  small integral membrane protein 3 isoform X6

      See identical proteins and their annotated locations for XP_006254831.1

      UniProtKB/Swiss-Prot
      Q99PE6
      UniProtKB/TrEMBL
      A6IXB1
      Conserved Domains (1) summary
      pfam17307
      Location:1 → 60
      Smim3; Small integral membrane protein 3

    8. XM_063277151.1 → XP_063133221.1  small integral membrane protein 3 isoform X5

    9. XM_063277150.1 → XP_063133220.1  small integral membrane protein 3 isoform X4

    10. XM_063277152.1 → XP_063133222.1  small integral membrane protein 3 isoform X5

    11. XM_063277146.1 → XP_063133216.1  small integral membrane protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GG85

    12. XM_063277148.1 → XP_063133218.1  small integral membrane protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GG85

    13. XM_017600863.3 → XP_017456352.1  small integral membrane protein 3 isoform X6

      UniProtKB/Swiss-Prot
      Q99PE6
      UniProtKB/TrEMBL
      A6IXB1
      Conserved Domains (1) summary
      pfam17307
      Location:1 → 60
      Smim3; Small integral membrane protein 3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PE6.1 GenPept UniProtKB/Swiss-Prot:Q99PE6

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