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    Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294513, updated on 27-Mar-2024

    Summary

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    Official Symbol
    Dnajb12provided by RGD
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B12provided by RGD
    Primary source
    RGD:1359677
    See related
    Ensembl:ENSRNOG00000030408 AllianceGenome:RGD:1359677
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable Hsp70 protein binding activity. Predicted to be involved in several processes, including cellular response to misfolded protein; chaperone cofactor-dependent protein refolding; and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum and nuclear membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 167.8), Muscle (RPKM 147.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnajb12 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (28371180..28389390)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (27828216..27846428)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (29445510..29463739)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene fatty acid binding protein 5, pseudogene 3 Neighboring gene mitochondrial calcium uptake 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120098848 Neighboring gene DNA-damage-inducible transcript 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR. Yamamoto YH, et al. Cell Struct Funct, 2010. PMID 21150129
    2. The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508. Grove DE, et al. Mol Biol Cell, 2011 Feb 1. PMID 21148293, Free PMC Article
    3. Tetrameric Assembly of K(+) Channels Requires ER-Located Chaperone Proteins. Li K, et al. Mol Cell, 2017 Jan 5. PMID 27916661
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94679

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to misfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to misfolded protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 12
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013907.3 → NP_001013929.1  dnaJ homolog subfamily B member 12

      See identical proteins and their annotated locations for NP_001013929.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      Q5FVC4
      Conserved Domains (2) summary
      pfam00226
      Location:111 → 172
      DnaJ; DnaJ domain
      pfam09320
      Location:269 → 369
      DUF1977; Domain of unknown function (DUF1977)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      28371180..28389390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098616.2 → XP_038954544.1  dnaJ homolog subfamily B member 12 isoform X1

      UniProtKB/TrEMBL
      A6K3V6, F7F4L4
      Related
      ENSRNOP00000049600.4
      Conserved Domains (2) summary
      TIGR02349
      Location:111 → 237
      DnaJ_bact; chaperone protein DnaJ
      pfam09320
      Location:269 → 369
      DUF1977; Domain of unknown function (DUF1977)
    Nucleotide Protein Strain
    Heading Accession and Version

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