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    Lcmt2 leucine carboxyl methyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296098, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lcmt2provided by RGD
    Official Full Name
    leucine carboxyl methyltransferase 2provided by RGD
    Primary source
    RGD:1305829
    See related
    Ensembl:ENSRNOG00000043002 AllianceGenome:RGD:1305829
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable tRNA methyltransferase activity. Predicted to be involved in tRNA methylation and wybutosine biosynthetic process. Orthologous to human LCMT2 (leucine carboxyl methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See Lcmt2 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128553707..128555831, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108099960..108102084, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113089646..113091770, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transglutaminase 5 Neighboring gene transglutaminase 7 Neighboring gene adenosine deaminase-like Neighboring gene zinc finger and SCAN domain containing 29, pseudogene 1 Neighboring gene tubulin gamma complex component 4 Neighboring gene tumor protein p53 binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wybutosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA wybutosine-synthesizing protein 4
    Names
    tRNA wybutosine-synthesizing protein 4 homolog
    tRNA yW-synthesizing protein 4 homolog
    tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase
    tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase
    NP_001011956.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011956.1 → NP_001011956.1  tRNA wybutosine-synthesizing protein 4

      See identical proteins and their annotated locations for NP_001011956.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083783
      UniProtKB/Swiss-Prot
      Q5XIA3
      Related
      ENSRNOP00000060993.1, ENSRNOT00000068132.3
      Conserved Domains (2) summary
      pfam04072
      Location:26 → 207
      LCM; Leucine carboxyl methyltransferase
      pfam13415
      Location:494 → 542
      Kelch_3; Galactose oxidase, central domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      128553707..128555831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIA3.1 GenPept UniProtKB/Swiss-Prot:Q5XIA3

    Gene LinkOut

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