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    Tasp1 taspase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311468, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Tasp1provided by RGD
    Official Full Name
    taspase 1provided by RGD
    Primary source
    RGD:1308591
    See related
    Ensembl:ENSRNOG00000004493 AllianceGenome:RGD:1308591
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308591
    Summary
    Predicted to enable identical protein binding activity and threonine-type endopeptidase activity. Predicted to be involved in positive regulation of transcription, DNA-templated; protein maturation; and proteolysis. Predicted to be active in cytoplasm. Orthologous to human TASP1 (taspase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 79.5), Brain (RPKM 59.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tasp1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (147630092..147861710, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (127176416..127408039, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (132888785..133131213, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101715 Neighboring gene serine palmitoyltransferase, long chain base subunit 3 Neighboring gene isthmin 1 Neighboring gene lactate dehydrogenase A, pseudogene 10 Neighboring gene uncharacterized LOC120101716 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 87 Neighboring gene ESF1 nucleolar pre-rRNA processing protein homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chemico-genetic strategies to inhibit the leukemic potential of threonine aspartase-1. Wünsch D, et al. Blood Cancer J, 2012 Jun. PMID 22829979, Free PMC Article
    2. Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. Khan JA, et al. Structure, 2005 Oct. PMID 16216576
    3. Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Hsieh JJ, et al. Cell, 2003 Oct 31. PMID 14636557
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125209

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables threonine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    threonine aspartase 1
    Names
    taspase, threonine aspartase 1
    NP_001037708.1
    XP_017447248.1
    XP_038960948.1
    XP_038960949.1
    XP_038960954.1
    XP_038960955.1
    XP_038960956.1
    XP_063139856.1
    XP_063139857.1
    XP_063139858.1
    XP_063139859.1
    XP_063139860.1
    XP_063139861.1
    XP_063139862.1
    XP_063139863.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044243.1 → NP_001037708.1  threonine aspartase 1

      See identical proteins and their annotated locations for NP_001037708.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105618
      UniProtKB/TrEMBL
      A0A8I5ZZW5, A6HQL8, F7F9N0, Q0VGK5
      Related
      ENSRNOP00000052492.2, ENSRNOT00000055630.4
      Conserved Domains (1) summary
      cd04514
      Location:42 → 416
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      147630092..147861710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105021.2 → XP_038960949.1  threonine aspartase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZW5, A6HQL8, F7F9N0, Q0VGK5
      Conserved Domains (1) summary
      cd04514
      Location:42 → 416
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    2. XM_039105020.1 → XP_038960948.1  threonine aspartase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZW5
      Conserved Domains (1) summary
      cd04514
      Location:42 → 434
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    3. XM_039105026.2 → XP_038960954.1  threonine aspartase 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZZW5
      Conserved Domains (1) summary
      cd04514
      Location:2 → 347
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    4. XM_063283790.1 → XP_063139860.1  threonine aspartase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZZW5

    5. XM_063283786.1 → XP_063139856.1  threonine aspartase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZZW5, A6HQL8, F7F9N0, Q0VGK5

    6. XM_063283793.1 → XP_063139863.1  threonine aspartase 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZZW5

    7. XM_063283791.1 → XP_063139861.1  threonine aspartase 1 isoform X6

      UniProtKB/TrEMBL
      A0A0G2KA32, A0A8I5ZZW5

    8. XM_063283789.1 → XP_063139859.1  threonine aspartase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZZW5

    9. XM_063283788.1 → XP_063139858.1  threonine aspartase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZZW5

    10. XM_063283787.1 → XP_063139857.1  threonine aspartase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZZW5

    11. XM_017591759.3 → XP_017447248.1  threonine aspartase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZW5
      Conserved Domains (1) summary
      cd04514
      Location:42 → 434
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    12. XM_063283792.1 → XP_063139862.1  threonine aspartase 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZZW5

    13. XM_039105027.1 → XP_038960955.1  threonine aspartase 1 isoform X9

      Conserved Domains (1) summary
      cd04514
      Location:1 → 297
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    14. XM_039105028.2 → XP_038960956.1  threonine aspartase 1 isoform X10

      Conserved Domains (1) summary
      cd04514
      Location:46 → 230
      Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

    RNA

    1. XR_010064632.1 RNA Sequence

    2. XR_010064631.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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