Sox7 SRY-box transcription factor 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sox7provided by RGD
Official Full Name: SRY-box transcription factor 7provided by RGD
Primary source: RGD:1310038
See related: Ensembl:ENSRNOG00000012049 AllianceGenome:RGD:1310038
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including endoderm formation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; and regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within positive regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Orthologous to human SOX7 (SRY-box transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 97.1), Heart (RPKM 50.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (42356405..42363166)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (38180503..38187264)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (47293699..47300460)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

demonstrated the anti-apoptosis ability of FTX during epileptogenesis and uncovered a novel FTX-mediated mechanism in status epilepticus-induced neural apoptosis by targeting miR-21-5p/SOX7 axis, which provides a new target in developing lncRNA-based strategies to reduce SE-induced hippocampal neuron apoptosis
Title: LncRNA FTX inhibits hippocampal neuron apoptosis by regulating miR-21-5p/SOX7 axis in a rat model of temporal lobe epilepsy.
Findings demonstrated that SOX7 interfered with beta-catenin activity to promote neuronal apoptosis, which acted as a novel signaling mechanism in neuronal cell death.
Title: SOX7 interferes with β-catenin activity to promote neuronal apoptosis.

Submit: New GeneRIF Correction

General gene information

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Markers

RH131053 (e-PCR)
- UniSTS:214336

Sox7 (e-PCR), detects polymorphism
- UniSTS:144492

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoderm formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor SOX-7

Names: SRY (sex determining region Y)-box 7; SRY box 7; SRY-box containing gene 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106045.1 → NP_001099515.1 transcription factor SOX-7

See identical proteins and their annotated locations for NP_001099515.1

Status: PROVISIONAL

Source sequence(s)

CH474023

UniProtKB/TrEMBL

A6K6G8, D3ZTE1

Related

ENSRNOP00000016503.4, ENSRNOT00000016503.5

Conserved Domains (2) summary

cd01388
Location:44 → 115

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam12067
Location:178 → 381

Sox_C_TAD; Sox C-terminal transactivation domain