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    Tusc3 tumor suppressor candidate 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290783, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tusc3provided by RGD
    Official Full Name
    tumor suppressor candidate 3provided by RGD
    Primary source
    RGD:1303318
    See related
    Ensembl:ENSRNOG00000013061 AllianceGenome:RGD:1303318
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable magnesium ion transmembrane transporter activity and oligosaccharyltransferase complex binding activity. Predicted to be involved in cognition; magnesium ion transport; and protein N-linked glycosylation via asparagine. Predicted to be located in mitochondrion. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TUSC3 (tumor suppressor candidate 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 584.1), Kidney (RPKM 216.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tusc3 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (59899642..60048813, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (53196195..53345241, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (56248125..56396491)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10A, pseudogene 10 Neighboring gene SMAD family member 2, pseudogene 1 Neighboring gene uncharacterized LOC134482387 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tumor suppressor candidate TUSC3 expression during rat testis maturation. Khalid AM, et al. Biosci Biotechnol Biochem, 2013. PMID 24096664
    2. Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation. Cherepanova NA, et al. Sci Rep, 2016 Feb 11. PMID 26864433, Free PMC Article
    3. Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22. MacGrogan D, et al. Genomics, 1996 Jul 1. PMID 8661104
    4. Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation. Molinari F, et al. Am J Hum Genet, 2008 May. PMID 18455129, Free PMC Article
    5. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Zhou H, et al. Proc Natl Acad Sci U S A, 2009 Sep 15. PMID 19717468, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94243

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in magnesium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in magnesium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in magnesium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oligosaccharyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tumor suppressor candidate 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004212.1 → NP_001004212.1  tumor suppressor candidate 3 precursor

      See identical proteins and their annotated locations for NP_001004212.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079193
      UniProtKB/TrEMBL
      A0A0G2KAE2, F7EPX8, Q6AY49
      Related
      ENSRNOP00000017452.4, ENSRNOT00000017452.6
      Conserved Domains (2) summary
      cd02947
      Location:73 → 183
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam04756
      Location:179 → 323
      OST3_OST6; OST3 / OST6 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      59899642..60048813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771294.3 → XP_008769516.1  tumor suppressor candidate 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KAE2, A0A8I6AVS1
      Related
      ENSRNOP00000098003.1
      Conserved Domains (2) summary
      cd02947
      Location:73 → 183
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      pfam04756
      Location:179 → 293
      OST3_OST6; OST3 / OST6 family

    2. XM_039094389.2 → XP_038950317.1  tumor suppressor candidate 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2KAE2

    3. XM_039094388.2 → XP_038950316.1  tumor suppressor candidate 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAE2
      Conserved Domains (1) summary
      pfam04756
      Location:54 → 342
      OST3_OST6; OST3 / OST6 family, transporter family
    Nucleotide Protein Strain
    Heading Accession and Version

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