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    Prag1 PEAK1 related kinase activating pseudokinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306506, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Prag1provided by RGD
    Official Full Name
    PEAK1 related kinase activating pseudokinase 1provided by RGD
    Primary source
    RGD:1311793
    See related
    Ensembl:ENSRNOG00000011407 AllianceGenome:RGD:1311793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pragmin; RGD1311793
    Summary
    Enables identical protein binding activity. Involved in several processes, including negative regulation of neuron projection development; positive regulation of Rho protein signal transduction; and regulation of cell shape. Located in cytoplasm and focal adhesion. Orthologous to human PRAG1 (PEAK1 related, kinase-activating pseudokinase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 28.7), Brain (RPKM 25.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prag1 in Genome Data Viewer
    Location:
    16q12.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (62791249..62844532, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (56087885..56141153, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (59666794..59730681, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene LON peptidase N-terminal domain and ring finger 1 Neighboring gene uncharacterized LOC120097451 Neighboring gene uncharacterized LOC102552468 Neighboring gene uncharacterized LOC120097468 Neighboring gene uncharacterized LOC120097487

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association. Patel O, et al. Nat Commun, 2017 Oct 27. PMID 29079850, Free PMC Article
    2. Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors. Safari F, et al. Proc Natl Acad Sci U S A, 2011 Sep 6. PMID 21873224, Free PMC Article
    3. Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation. Lecointre C, et al. Structure, 2018 Apr 3. PMID 29503074
    4. C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility. Senda Y, et al. Cancer Sci, 2016 Jul. PMID 27116701, Free PMC Article
    5. NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. Weaver KL, et al. Cancer Res, 2014 Sep 1. PMID 25038227, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inactive tyrosine-protein kinase PRAG1
    Names
    pragma of Rnd2
    tyrosine-protein kinase SgK223
    NP_001100785.1
    XP_038950470.1
    XP_038950471.1
    XP_038950472.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107315.1 → NP_001100785.1  inactive tyrosine-protein kinase PRAG1

      See identical proteins and their annotated locations for NP_001100785.1

      Status: VALIDATED

      Source sequence(s)
      CH473970
      UniProtKB/Swiss-Prot
      D3ZMK9
      Related
      ENSRNOP00000015166.5, ENSRNOT00000015166.7
      Conserved Domains (2) summary
      PHA03307
      Location:377 → 607
      PHA03307; transcriptional regulator ICP4; Provisional
      cl21453
      Location:1012 → 1292
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      62791249..62844532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094542.2 → XP_038950470.1  inactive tyrosine-protein kinase PRAG1 isoform X1

      UniProtKB/Swiss-Prot
      D3ZMK9
      Conserved Domains (2) summary
      PHA03307
      Location:377 → 607
      PHA03307; transcriptional regulator ICP4; Provisional
      cl21453
      Location:1012 → 1292
      PKc_like; Protein Kinases, catalytic domain

    2. XM_039094544.2 → XP_038950472.1  inactive tyrosine-protein kinase PRAG1 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:316 → 596
      PKc_like; Protein Kinases, catalytic domain

    3. XM_039094543.2 → XP_038950471.1  inactive tyrosine-protein kinase PRAG1 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:316 → 596
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZMK9.1 GenPept UniProtKB/Swiss-Prot:D3ZMK9

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