Dnmt3a DNA methyltransferase 3 alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnmt3aprovided by RGD
Official Full Name: DNA methyltransferase 3 alphaprovided by RGD
Primary source: RGD:1303336
See related: Ensembl:ENSRNOG00000026649 AllianceGenome:RGD:1303336
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables chromatin binding activity. Involved in several processes, including cellular response to ethanol; hepatocyte apoptotic process; and response to vitamin A. Located in cytoplasm and nucleus. Used to study lung carcinoma and middle cerebral artery infarction. Biomarker of congenital heart disease; hepatocellular carcinoma; and prostatitis. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; myelodysplastic syndrome; and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 116.0), Brain (RPKM 112.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (32507316..32621678)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (26791517..26902161)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (28205375..28346052)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNMT3a-mediated methylation of PPARgamma promote intervertebral disc degeneration by regulating the NF-kappaB pathway.
Title: DNMT3a-mediated methylation of PPARγ promote intervertebral disc degeneration by regulating the NF-κB pathway.
miR-199a-3p mediates bone cancer pain through upregulation of dnmt3a expression in spinal dorsal horn neurons.
Title: miR-199a-3p mediates bone cancer pain through upregulation of dnmt3a expression in spinal dorsal horn neurons.
POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment.
Title: POU2F1/DNMT3a Pathway Participates in Neuropathic Pain by Hypermethylation-Mediated LRFN4 Downregulation Following Oxaliplatin Treatment.
Identification of Epigenetic Interactions between MicroRNA-30c-5p and DNA Methyltransferases in Neuropathic Pain.
Title: Identification of Epigenetic Interactions between MicroRNA-30c-5p and DNA Methyltransferases in Neuropathic Pain.
DNA Methyltransferase 3A Is Involved in the Sustained Effects of Chronic Stress on Synaptic Functions and Behaviors.
Title: DNA Methyltransferase 3A Is Involved in the Sustained Effects of Chronic Stress on Synaptic Functions and Behaviors.
Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity.
Title: Ube2b-dependent degradation of DNMT3a relieves a transcriptional brake on opiate-induced synaptic and behavioral plasticity.
DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats.
Title: DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self-administration in rats.
our results highlight miR-369-5p mediated DNMT3A epigenetic silencing of Patched1 as a mechanism of fibroblast proliferation in cardiac fibrosis
Title: Epigenetic aberrations of miR-369-5p and DNMT3A control Patched1 signal pathway in cardiac fibrosis.
Peripheral nerve injury increases expression of the DNA methyltransferase DNMT3a in the injured DRG neurons via the activation of the transcription factor octamer transcription factor 1. Blocking this increase prevents nerve injury-induced methylation of the voltage-dependent potassium (Kv) channel subunit Kcna2 promoter region and rescues Kcna2 expression in the injured DRG and attenuates neuropathic pain.
Title: DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.
DNMT3A level was upregulated and negatively correlated with miR-200b expression in fibrosis tissues and cardiac fibroblasts. Our results provide a basis for understanding the molecular mechanism by which DNMT3A and miR-200b, in combination with rapamycin, upregulates autophagic activity.
Title: DNMT3A controls miR-200b in cardiac fibroblast autophagy and cardiac fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_26721-26722:1034781098:3 (e-PCR)
- UniSTS:269059

RH135183 (e-PCR)
- UniSTS:218460

RH139204 (e-PCR)
- UniSTS:221290

BF398717 (e-PCR)
- UniSTS:246897

Dnmt3a (e-PCR), detects polymorphism
- UniSTS:525684

BE113641 (e-PCR)
- UniSTS:246739

RH130466 (e-PCR)
- UniSTS:213750

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA (cytosine-5-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA (cytosine-5-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables DNA (cytosine-5-)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-cysteine methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein-cysteine methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables unmethylated CpG binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA methylation-dependent heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in DNA methylation-dependent heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autosome genomic imprinting	ISO Inferred from Sequence Orthology more info
involved_in autosome genomic imprinting	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to bisphenol A	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within epigenetic programming of gene expression	ISO Inferred from Sequence Orthology more info
involved_in epigenetic programming of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within genomic imprinting	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ionizing radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in XY body	ISO Inferred from Sequence Orthology more info
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of euchromatin	ISO Inferred from Sequence Orthology more info
part_of euchromatin	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of heterochromatin	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: DNA (cytosine-5)-methyltransferase 3A

Names: DNA (cytosine-5-)-methyltransferase 3 alpha; DNA methyltransferase 3A; cysteine methyltransferase DNMT3A

NP_001003957.1

EC 2.1.1.37

NP_001003958.1

EC 2.1.1.37

XP_017449756.1

EC 2.1.1.37

XP_017449757.1

EC 2.1.1.37

XP_038968589.1

EC 2.1.1.37

XP_038968590.1

EC 2.1.1.37

XP_038968591.1

EC 2.1.1.37

XP_038968592.1

EC 2.1.1.37

XP_038968594.1

EC 2.1.1.37

XP_038968595.1

EC 2.1.1.37

XP_038968596.1

EC 2.1.1.37

XP_063118331.1

EC 2.1.1.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003957.1 → NP_001003957.1 DNA (cytosine-5)-methyltransferase 3A isoform 2

See identical proteins and their annotated locations for NP_001003957.1

Status: PROVISIONAL

Source sequence(s)

BN000396

UniProtKB/Swiss-Prot

Q1LZ53

Conserved Domains (3) summary

cd05835
Location:67 → 153

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

cd11729
Location:264 → 391

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:409 → 572

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
NM_001003958.1 → NP_001003958.1 DNA (cytosine-5)-methyltransferase 3A isoform 1

See identical proteins and their annotated locations for NP_001003958.1

Status: PROVISIONAL

Source sequence(s)

BN000395

UniProtKB/Swiss-Prot

Q1LZ52, Q1LZ53

Related

ENSRNOP00000046524.2, ENSRNOT00000047210.4

Conserved Domains (4) summary

cd05835
Location:286 → 372

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

PTZ00449
Location:1 → 121

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11729
Location:483 → 610

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:628 → 791

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

32507316..32621678

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594268.3 → XP_017449757.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/Swiss-Prot

Q1LZ52, Q1LZ53

Conserved Domains (4) summary

cd05835
Location:286 → 372

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

PTZ00449
Location:1 → 121

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11729
Location:483 → 610

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:628 → 791

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
XM_017594267.3 → XP_017449756.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/Swiss-Prot

Q1LZ52, Q1LZ53

Conserved Domains (4) summary

cd05835
Location:286 → 372

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

PTZ00449
Location:1 → 121

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11729
Location:483 → 610

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:628 → 791

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
XM_039112664.1 → XP_038968592.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/Swiss-Prot

Q1LZ52, Q1LZ53

Conserved Domains (4) summary

cd05835
Location:286 → 372

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

PTZ00449
Location:1 → 121

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11729
Location:483 → 610

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:628 → 791

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
XM_039112661.2 → XP_038968589.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/Swiss-Prot

Q1LZ52, Q1LZ53

Conserved Domains (4) summary

cd05835
Location:286 → 372

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

PTZ00449
Location:1 → 121

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11729
Location:483 → 610

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:628 → 791

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
XM_039112666.2 → XP_038968594.1 DNA (cytosine-5)-methyltransferase 3A isoform X2

Conserved Domains (4) summary

cd05835
Location:286 → 372

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

PTZ00449
Location:1 → 121

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11729
Location:483 → 610

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:628 → 791

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
XM_039112663.2 → XP_038968591.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/Swiss-Prot

Q1LZ52, Q1LZ53

Conserved Domains (4) summary

cd05835
Location:286 → 372

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

PTZ00449
Location:1 → 121

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11729
Location:483 → 610

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:628 → 791

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
XM_039112662.2 → XP_038968590.1 DNA (cytosine-5)-methyltransferase 3A isoform X1

UniProtKB/Swiss-Prot

Q1LZ52, Q1LZ53

Conserved Domains (4) summary

cd05835
Location:286 → 372

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

PTZ00449
Location:1 → 121

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

cd11729
Location:483 → 610

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:628 → 791

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
XM_063262261.1 → XP_063118331.1 DNA (cytosine-5)-methyltransferase 3A isoform X4
XM_039112667.2 → XP_038968595.1 DNA (cytosine-5)-methyltransferase 3A isoform X3

UniProtKB/TrEMBL

A6HAG2

Conserved Domains (3) summary

cd05835
Location:106 → 192

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

cd11729
Location:303 → 430

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:448 → 611

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...
XM_039112668.2 → XP_038968596.1 DNA (cytosine-5)-methyltransferase 3A isoform X5

Conserved Domains (3) summary

cd05835
Location:67 → 153

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

cd11729
Location:264 → 391

ADDz_Dnmt3a; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3a (Dnmt3a)

cl30459
Location:409 → 572

Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...