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    Il20rb interleukin 20 receptor subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501043, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Il20rbprovided by RGD
    Official Full Name
    interleukin 20 receptor subunit betaprovided by RGD
    Primary source
    RGD:1566151
    See related
    Ensembl:ENSRNOG00000023214 AllianceGenome:RGD:1566151
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IL20R2; RGD1566151
    Summary
    Predicted to enable cytokine receptor activity and interleukin-20 binding activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within several processes, including negative regulation of T cell proliferation; negative regulation of type IV hypersensitivity; and regulation of cytokine production. Predicted to be integral component of plasma membrane. Orthologous to human IL20RB (interleukin 20 receptor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 38.3), Muscle (RPKM 13.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il20rb in Genome Data Viewer
    Location:
    8q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (109858108..109896066, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (100979085..101010829, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (108745906..108778561, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 4, pseudogene 1 Neighboring gene uncharacterized LOC120094241 Neighboring gene NCK adaptor protein 1 Neighboring gene solute carrier family 35, member G2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses. Wahl C, et al. J Immunol, 2009 Jan 15. PMID 19124723
    2. IL-19 is involved in the pathogenesis of endotoxic shock. Hsing CH, et al. Shock, 2008 Jan. PMID 18246602
    3. Anti-IL-20 monoclonal antibody inhibits the differentiation of osteoclasts and protects against osteoporotic bone loss. Hsu YH, et al. J Exp Med, 2011 Aug 29. PMID 21844205, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-20 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-20 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within CD8-positive, alpha-beta T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immune response-inhibiting signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of type IV hypersensitivity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of interleukin-4 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-20 receptor subunit beta
    Names
    interleukin 20 receptor beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173438.1 → NP_001166909.1  interleukin-20 receptor subunit beta

      See identical proteins and their annotated locations for NP_001166909.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ222846
      UniProtKB/TrEMBL
      B8K1X9
      Related
      ENSRNOP00000031089.4, ENSRNOT00000034188.5
      Conserved Domains (2) summary
      pfam01108
      Location:25 → 119
      Tissue_fac; Tissue factor
      cl21522
      Location:131 → 220
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      109858108..109896066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265999.1 → XP_063122069.1  interleukin-20 receptor subunit beta isoform X3

    2. XM_039081976.2 → XP_038937904.1  interleukin-20 receptor subunit beta isoform X2

      Conserved Domains (2) summary
      pfam01108
      Location:110 → 219
      Tissue_fac; Tissue factor
      cl21522
      Location:231 → 343
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_017595846.3 → XP_017451335.1  interleukin-20 receptor subunit beta isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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