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    Lpgat1 lysophosphatidylglycerol acyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679692, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Lpgat1provided by RGD
    Official Full Name
    lysophosphatidylglycerol acyltransferase 1provided by RGD
    Primary source
    RGD:1585897
    See related
    Ensembl:ENSRNOG00000004402 AllianceGenome:RGD:1585897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 2-acylglycerol O-acyltransferase activity and lysophospholipid acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling; positive regulation of fatty acid biosynthetic process; and triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human LPGAT1 (lysophosphatidylglycerol acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 371.4), Brain (RPKM 204.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lpgat1 in Genome Data Viewer
    Location:
    13q27
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105825630..105896366)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (103294622..103365372)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (110397353..110470874)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S18, pseudogene 10 Neighboring gene ribosomal protein L37 like 2 Neighboring gene uncharacterized LOC102555670 Neighboring gene uncharacterized LOC120096356 Neighboring gene NIMA-related kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Soh J, et al. Nat Med, 2013 Jul. PMID 23749231, Free PMC Article
    2. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2-acylglycerol O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 2-acylglycerophosphocholine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophosphatidylethanolamine acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophospholipid acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylethanolamine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA:lysophosphatidylglycerol acyltransferase 1
    NP_001102846.1
    XP_038947018.1
    XP_038947019.1
    XP_063128667.1
    XP_063128668.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109376.2 → NP_001102846.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1

      See identical proteins and their annotated locations for NP_001102846.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JH01, F1LTX8
      Conserved Domains (2) summary
      cd07990
      Location:69 → 285
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:274 → 329
      Acyltransf_C; Acyltransferase C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      105825630..105896366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091091.1 → XP_038947019.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JH01, F1LTX8
      Conserved Domains (2) summary
      cd07990
      Location:69 → 285
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:274 → 329
      Acyltransf_C; Acyltransferase C-terminus

    2. XM_063272597.1 → XP_063128667.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JH01, F1LTX8

    3. XM_039091090.2 → XP_038947018.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JH01, F1LTX8
      Conserved Domains (2) summary
      cd07990
      Location:69 → 285
      LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
      pfam16076
      Location:274 → 329
      Acyltransf_C; Acyltransferase C-terminus

    4. XM_063272598.1 → XP_063128668.1  acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JH01, F1LTX8
    Nucleotide Protein Strain
    Heading Accession and Version

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