Rps6kc1 ribosomal protein S6 kinase polypeptide 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps6kc1provided by MGI
Official Full Name: ribosomal protein S6 kinase polypeptide 1provided by MGI
Primary source: MGI:MGI:2443419
See related: Ensembl:ENSMUSG00000089872 AllianceGenome:MGI:2443419
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rpk118; B130003F20Rik
Summary: Predicted to enable ATP binding activity; phosphatidylinositol binding activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Is active in postsynaptic density. Is expressed in olfactory epithelium and vomeronasal organ. Orthologous to human RPS6KC1 (ribosomal protein S6 kinase C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cortex adult (RPKM 3.4), CNS E14 (RPKM 3.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 96.2 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (190505076..190645207, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (190772879..190913010, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234304

MTH1884 (e-PCR)
- UniSTS:128832

D1Mit462.2 (e-PCR), detects polymorphism
- UniSTS:128833

RH124353 (e-PCR)
- UniSTS:161175

RH126952 (e-PCR)
- UniSTS:207271

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	EXP Inferred from Experiment more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ribosomal protein S6 kinase delta-1

Names: 52 kDa ribosomal protein S6 kinase; S6K-delta-1; ribosomal protein S6 kinase, 52kDa, polypeptide 1

NP_848890.3

EC 2.7.11.1

XP_006497235.1

EC 2.7.11.1

XP_006497236.1

EC 2.7.11.1

XP_006497237.1

EC 2.7.11.1

XP_006497238.1

EC 2.7.11.1

XP_011237223.1

EC 2.7.11.1

XP_030110821.1

EC 2.7.11.1

XP_030110822.1

EC 2.7.11.1

XP_036021590.1

EC 2.7.11.1

XP_036021591.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178775.4 → NP_848890.3 ribosomal protein S6 kinase delta-1

Status: VALIDATED

Source sequence(s)

AK149858, BC058403, BG079911, CJ045347

UniProtKB/Swiss-Prot

Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49

UniProtKB/TrEMBL

E9QMX4

Related

ENSMUSP00000061769.9, ENSMUST00000061611.15

Conserved Domains (5) summary

cd07287
Location:11 → 128

PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins

smart00220
Location:864 → 1046

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd02677
Location:237 → 309

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:869 → 1046

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl21453
Location:334 → 427

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

190505076..190645207 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497172.4 → XP_006497235.1 ribosomal protein S6 kinase delta-1 isoform X1

UniProtKB/Swiss-Prot

Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49

Conserved Domains (4) summary

cd02677
Location:225 → 297

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:857 → 1034

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl02563
Location:11 → 116

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl21453
Location:322 → 415

PKc_like; Protein Kinases, catalytic domain
XM_006497175.4 → XP_006497238.1 ribosomal protein S6 kinase delta-1 isoform X4

UniProtKB/Swiss-Prot

Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49

Conserved Domains (4) summary

cd07287
Location:11 → 128

PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins

cd05576
Location:749 → 926

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl00299
Location:155 → 189

MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...

cl21453
Location:214 → 307

PKc_like; Protein Kinases, catalytic domain
XM_006497173.4 → XP_006497236.1 ribosomal protein S6 kinase delta-1 isoform X2

UniProtKB/Swiss-Prot

Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49

Conserved Domains (4) summary

cd07287
Location:11 → 128

PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins

cd02677
Location:237 → 309

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:838 → 1015

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl21453
Location:305 → 396

PKc_like; Protein Kinases, catalytic domain
XM_006497174.4 → XP_006497237.1 ribosomal protein S6 kinase delta-1 isoform X3

UniProtKB/Swiss-Prot

Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49

Conserved Domains (3) summary

cd07287
Location:11 → 128

PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins

cd02677
Location:237 → 309

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cl21453
Location:869 → 960

PKc_like; Protein Kinases, catalytic domain
XM_030254962.1 → XP_030110822.1 ribosomal protein S6 kinase delta-1 isoform X6

Conserved Domains (3) summary

cd02677
Location:56 → 128

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:657 → 834

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl21453
Location:124 → 215

PKc_like; Protein Kinases, catalytic domain
XM_030254961.1 → XP_030110821.1 ribosomal protein S6 kinase delta-1 isoform X5

UniProtKB/Swiss-Prot

Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49

Conserved Domains (3) summary

cd02677
Location:56 → 128

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:688 → 865

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl21453
Location:153 → 246

PKc_like; Protein Kinases, catalytic domain
XM_011238921.2 → XP_011237223.1 ribosomal protein S6 kinase delta-1 isoform X5

UniProtKB/Swiss-Prot

Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49

Conserved Domains (3) summary

cd02677
Location:56 → 128

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:688 → 865

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl21453
Location:153 → 246

PKc_like; Protein Kinases, catalytic domain
XM_036165697.1 → XP_036021590.1 ribosomal protein S6 kinase delta-1 isoform X5

UniProtKB/Swiss-Prot

Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49

Conserved Domains (3) summary

cd02677
Location:56 → 128

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cd05576
Location:688 → 865

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

cl21453
Location:153 → 246

PKc_like; Protein Kinases, catalytic domain
XM_036165698.1 → XP_036021591.1 ribosomal protein S6 kinase delta-1 isoform X7

Conserved Domains (1) summary

cd05576
Location:434 → 611

STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins