Tmem108 transmembrane protein 108 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem108provided by MGI
Official Full Name: transmembrane protein 108provided by MGI
Primary source: MGI:MGI:1932411
See related: Ensembl:ENSMUSG00000042757 AllianceGenome:MGI:1932411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B130017P16Rik
Summary: Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Located in several cellular components, including axon; endosome; and postsynaptic density. Is expressed in 4th ventricle lateral recess; cerebral cortex marginal layer; and lateral ventricle choroid plexus. Orthologous to human TMEM108 (transmembrane protein 108). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cerebellum adult (RPKM 2.3), CNS E18 (RPKM 2.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 55.47 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (103360135..103639099, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (103482936..103761900, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis.
Title: The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis.
Tmem108 is enriched in DG granule neurons. Its expression increased at the postnatal period critical for DG development. Tmem108 is specifically expressed in the nervous system and enriched in the postsynaptic density fraction. Tmem108 is required for spine formation and maturation and AMPA receptor expression. EPSCs were decreased in Tmem108 mutant mice, which have compromised sensorimotor gating and cognitive functions.
Title: Transmembrane protein 108 is required for glutamatergic transmission in dentate gyrus.
retrolinkin functions in the endocytic trafficking of BDNF-TrkB and mediates BDNF-triggered ERK signaling in CNS neurons
Title: Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

D12Bwg0892e (e-PCR), detects polymorphism
- UniSTS:141838

D9Dcr45 (e-PCR), detects polymorphism
- UniSTS:498968

C86942 (e-PCR)
- UniSTS:208437

01.MMHAP90FRA7.seq (e-PCR)
- UniSTS:122679

AI462967 (e-PCR)
- UniSTS:164414

R74726 (e-PCR)
- UniSTS:125515

D9Mit14 (e-PCR), detects polymorphism
- UniSTS:131689

D9Mit14.1 (e-PCR), detects polymorphism
- UniSTS:131690

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to brain-derived neurotrophic factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite extension	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dentate gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurotrophin TRK receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic density organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic density organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde axonal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde axonal transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in somatodendritic compartment	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 108

Names: retrolinkin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.