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    FUC1 alpha-L-fucosidase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817355, updated on 15-Oct-2023

    Summary

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    Gene symbol
    FUC1
    Gene description
    alpha-L-fucosidase 1
    Primary source
    Araport:AT2G28100
    Locus tag
    AT2G28100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    alpha-L-fucosidase 1; ATFUC1; F24D13.11; F24D13_11
    Summary
    Encodes a protein with alpha-fucosidase activity. The activity was assessed on 2'-fucosyl-lactitol. AtFUC1 was not able to act on XXFG substrates, at least when heterologously expressed in <i>Pichia pastoris</i>. The enzyme has been postulated to act on fucosylated substrates other than xyloglucan oligosaccharides. was shown (<i>Pichia pastoris</i>) to hydrolyze fucose in 3- and 4-linkage, hence was characterized as alpha-L-3,4-fucosidase
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    Genomic context

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    See FUC1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (11974663..11976600)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene ncRNA Neighboring gene replication factor-A carboxy-terminal domain protein Neighboring gene Exostosin family protein Neighboring gene Major facilitator superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Degradation pathway of plant complex-type N-glycans: identification and characterization of a key α1,3-fucosidase from glycoside hydrolase family 29. Kato S, et al. Biochem J, 2018 Jan 11. PMID 29212795
    2. Molecular cloning and characterization of a plant alpha1,3/4-fucosidase based on sequence tags from almond fucosidase I. Zeleny R, et al. Phytochemistry, 2006 Apr. PMID 16516937
    3. AtFXG1, an Arabidopsis gene encoding alpha-L-fucosidase active against fucosylated xyloglucan oligosaccharides. de La Torre F, et al. Plant Physiol, 2002 Jan. PMID 11788770, Free PMC Article
    4. VH1/BRL2 receptor-like kinase interacts with vascular-specific adaptor proteins VIT and VIK to influence leaf venation. Ceserani T, et al. Plant J, 2009 Mar. PMID 19000166, Free PMC Article
    5. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results showed that FUC1 is an alpha-1,3-fucosidase acting on plant complex-type N-glycans and elucidated the degradation pathway of plant complex-type N-glycans.
      Title: Degradation pathway of plant complex-type N-glycans: identification and characterization of a key α1,3-fucosidase from glycoside hydrolase family 29.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128370.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alpha-L-fucosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycoprotein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    alpha-L-fucosidase 1
    NP_180377.2
    • alpha-L-fucosidase 1 (FUC1); FUNCTIONS IN: alpha-L-fucosidase activity; INVOLVED IN: glycoprotein catabolic process; LOCATED IN: vacuole; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 29 (InterPro:IPR000933), Glycoside hydrolase, catalytic core (InterPro:IPR017853), Glycoside hydrolase, subgroup, catalytic core (InterPro:IPR013781); Has 2006 Blast hits to 1993 proteins in 389 species: Archae - 18; Bacteria - 1470; Metazoa - 203; Fungi - 6; Plants - 70; Viruses - 0; Other Eukaryotes - 239 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11974663..11976600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128370.3 → NP_180377.2  alpha-L-fucosidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180377.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GW72, Q9ZUV2
      UniProtKB/TrEMBL
      A0A178VQ23, A0A5S9X1Y4, A0A654EYB3
      Conserved Domains (1) summary
      COG3669
      Location:28 → 477
      AfuC; Alpha-L-fucosidase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GW72.2

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