AT4G32060 calcium-binding EF hand family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: AT4G32060
Gene description: calcium-binding EF hand family protein
Primary source: Araport:AT4G32060
Locus tag: AT4G32060
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F10N7.140; F10N7_140
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Genomic context

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See AT4G32060 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 6

Sequence:: Chromosome: 4; NC_003075.7 (15500926..15503593)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MICU acts as a throttle that controls Ca(2+) uptake by moderating influx, thereby shaping Ca(2+) signatures in the matrix and preserving mitochondrial homeostasis.[MICU]
Title: The EF-Hand Ca2+ Binding Protein MICU Choreographs Mitochondrial Ca2+ Dynamics in Arabidopsis.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_001085007.1

Supported by ESTs:

NM_119358.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mitochondrial calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: calcium-binding EF hand family protein

NP_001078476.1

calcium-binding EF hand family protein; FUNCTIONS IN: calcium ion binding; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); Has 1096 Blast hits to 1078 proteins in 164 species: Archae - 0; Bacteria - 0; Metazoa - 829; Fungi - 82; Plants - 97; Viruses - 0; Other Eukaryotes - 88 (source: NCBI BLink).

NP_194934.1

calcium-binding EF hand family protein; FUNCTIONS IN: calcium ion binding; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); Has 1138 Blast hits to 1114 proteins in 164 species: Archae - 0; Bacteria - 0; Metazoa - 850; Fungi - 83; Plants - 103; Viruses - 0; Other Eukaryotes - 102 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

15500926..15503593

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119358.4 → NP_194934.1 calcium-binding EF hand family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194934.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8MRL1, Q9SZ45

UniProtKB/TrEMBL

A0A178UX91, A0A654FUT3

Conserved Domains (2) summary

cd00051
Location:216 → 273

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd15900
Location:248 → 469

EFh_MICU; EF-hand, calcium binding motif, found in mitochondrial calcium uptake proteins MICU1, MICU2, MICU3, and similar proteins
NM_001085007.1 → NP_001078476.1 calcium-binding EF hand family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078476.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UX91

Conserved Domains (2) summary

cd00051
Location:216 → 273

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:216 → 272

EF-hand_7; EF-hand domain pair