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    Naip6 NLR family, apoptosis inhibitory protein 6 [ Mus musculus (house mouse) ]

    Gene ID: 17952, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Naip6provided by MGI
    Official Full Name
    NLR family, apoptosis inhibitory protein 6provided by MGI
    Primary source
    MGI:MGI:1298222
    See related
    Ensembl:ENSMUSG00000078942 AllianceGenome:MGI:1298222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Birc1f; Naip-rs4; Naip-rs4A
    Summary
    Predicted to enable ATP binding activity and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in inflammatory response; pyroptosis; and response to bacterium. Acts upstream of or within cellular response to estrogen stimulus. Part of IPAF inflammasome complex. Is expressed in genitourinary system and spinal cord. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 23.3), small intestine adult (RPKM 13.1) and 7 other tissues See more
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    Genomic context

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    See Naip6 in Genome Data Viewer
    Location:
    13 D1; 13 53.09 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100417629..100453124, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100281121..100316616, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene NLR family, apoptosis inhibitory protein 2 Neighboring gene NLR family, apoptosis inhibitory protein 1, related sequence 1 Neighboring gene STARR-seq mESC enhancer starr_35472 Neighboring gene STARR-seq mESC enhancer starr_35473 Neighboring gene NLR family, apoptosis inhibitory protein 5 Neighboring gene STARR-seq mESC enhancer starr_35474 Neighboring gene NLR family, apoptosis inhibitory protein 3, pseudogene 1 Neighboring gene NLR family, apoptosis inhibitory protein 3 Neighboring gene ubiquitin specific peptidase 38 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Wright EK, et al. Curr Biol, 2003 Jan 8. PMID 12526741
    2. The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells. Götz R, et al. Hum Mol Genet, 2000 Oct 12. PMID 11030753
    3. The mouse Naip gene cluster on Chromosome 13 encodes several distinct functional transcripts. Huang S, et al. Mamm Genome, 1999 Oct. PMID 10501978
    4. NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo. Rauch I, et al. J Exp Med, 2016 May 2. PMID 27045008, Free PMC Article
    5. The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila. Diez E, et al. J Immunol, 2000 Feb 1. PMID 10640764

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyroptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyroptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of IPAF inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of IPAF inflammasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    baculoviral IAP repeat-containing protein 1f
    Names
    neuronal apoptosis inhibitory protein 6
    neuronal apoptosis inhibitory protein, related sequence 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010871.2 → NP_035001.2  baculoviral IAP repeat-containing protein 1f

      See identical proteins and their annotated locations for NP_035001.2

      Status: VALIDATED

      Source sequence(s)
      AF135494
      Consensus CDS
      CCDS26728.1
      UniProtKB/Swiss-Prot
      P81704, Q8CH68, Q9JIB6
      UniProtKB/TrEMBL
      Q8CH64
      Related
      ENSMUSP00000041766.3, ENSMUST00000042220.3
      Conserved Domains (6) summary
      cd09293
      Location:1072 → 1271
      AMN1; Antagonist of mitotic exit network protein 1
      smart00238
      Location:277 → 346
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:61 → 129
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      sd00034
      Location:1132 → 1156
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam00653
      Location:162 → 228
      BIR; Inhibitor of Apoptosis domain
      pfam05729
      Location:464 → 618
      NACHT; NACHT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      100417629..100453124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JIB6.2 GenPept UniProtKB/Swiss-Prot:Q9JIB6

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