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    Slc12a9 solute carrier family 12 (potassium/chloride transporters), member 9 [ Mus musculus (house mouse) ]

    Gene ID: 83704, updated on 12-May-2024

    Summary

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    Official Symbol
    Slc12a9provided by MGI
    Official Full Name
    solute carrier family 12 (potassium/chloride transporters), member 9provided by MGI
    Primary source
    MGI:MGI:1933532
    See related
    Ensembl:ENSMUSG00000037344 AllianceGenome:MGI:1933532
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CIP1
    Summary
    Predicted to enable potassium:chloride symporter activity. Predicted to be involved in cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Predicted to be integral component of membrane. Is expressed in genitourinary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human SLC12A9 (solute carrier family 12 member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 11.1), adrenal adult (RPKM 11.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc12a9 in Genome Data Viewer
    Location:
    5 G2; 5 76.35 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137312820..137338331, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137314558..137340070, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 43013 Neighboring gene thyroid hormone receptor interactor 6 Neighboring gene STARR-positive B cell enhancer ABC_E9655 Neighboring gene STARR-seq mESC enhancer starr_14641 Neighboring gene predicted gene, 52791 Neighboring gene Eph receptor B4 Neighboring gene STARR-seq mESC enhancer starr_14643

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CIP1 is an activator of the K+-Cl- cotransporter KCC2. Wenz M, et al. Biochem Biophys Res Commun, 2009 Apr 10. PMID 19232517
    2. Cation-chloride cotransporters and neuronal function. Blaesse P, et al. Neuron, 2009 Mar 26. PMID 19323993
    3. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Wilson MD, et al. Nucleic Acids Res, 2001 Mar 15. PMID 11239002, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 12 member 9
    Names
    cation-chloride cotransporter-interacting protein 1
    potassium-chloride transporter 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359611.1 → NP_001346540.1  solute carrier family 12 member 9

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC150682
      Consensus CDS
      CCDS19766.1
      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    2. NM_031406.3 → NP_113583.2  solute carrier family 12 member 9

      See identical proteins and their annotated locations for NP_113583.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC150682
      Consensus CDS
      CCDS19766.1
      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Related
      ENSMUSP00000038106.8, ENSMUST00000039991.14
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137312820..137338331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254934.2 → XP_030110794.1  solute carrier family 12 member 9 isoform X1

      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    2. XM_030254938.2 → XP_030110798.1  solute carrier family 12 member 9 isoform X1

      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    3. XM_030254937.2 → XP_030110797.1  solute carrier family 12 member 9 isoform X1

      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    4. XM_030254933.2 → XP_030110793.1  solute carrier family 12 member 9 isoform X1

      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    5. XM_036165634.1 → XP_036021527.1  solute carrier family 12 member 9 isoform X1

      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    6. XM_030254931.2 → XP_030110791.1  solute carrier family 12 member 9 isoform X1

      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    7. XM_030254935.2 → XP_030110795.1  solute carrier family 12 member 9 isoform X1

      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    8. XM_030254932.2 → XP_030110792.1  solute carrier family 12 member 9 isoform X1

      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    9. XM_030254936.1 → XP_030110796.1  solute carrier family 12 member 9 isoform X1

      UniProtKB/Swiss-Prot
      E9QNN4, Q99MR3
      Conserved Domains (1) summary
      TIGR00930
      Location:36 → 905
      2a30; K-Cl cotransporter

    RNA

    1. XR_001784760.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MR3.2 GenPept UniProtKB/Swiss-Prot:Q99MR3

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