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    Hexim2 hexamethylene bis-acetamide inducible 2 [ Mus musculus (house mouse) ]

    Gene ID: 71059, updated on 25-Jun-2024

    Summary

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    Official Symbol
    Hexim2provided by MGI
    Official Full Name
    hexamethylene bis-acetamide inducible 2provided by MGI
    Primary source
    MGI:MGI:1918309
    See related
    Ensembl:ENSMUSG00000043372 AllianceGenome:MGI:1918309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933402L21Rik
    Summary
    Predicted to enable 7SK snRNA binding activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; and identical protein binding activity. Predicted to be involved in negative regulation of cyclin-dependent protein serine/threonine kinase activity and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nuclear speck. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in heart. Orthologous to human HEXIM2 (HEXIM P-TEFb complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 10.3), CNS E18 (RPKM 3.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hexim2 in Genome Data Viewer
    Location:
    11 E1; 11 66.71 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103014086..103030734)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103123260..103139908)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E204 Neighboring gene acyl-Coenzyme A binding domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E4004 Neighboring gene STARR-positive B cell enhancer ABC_E738 Neighboring gene hexamethylene bis-acetamide inducible 1 Neighboring gene STARR-positive B cell enhancer ABC_E379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:103003747-103004003 Neighboring gene STARR-positive B cell enhancer ABC_E10717 Neighboring gene predicted gene, 51919 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:103036322-103036635 Neighboring gene formin-like 1 Neighboring gene uncharacterized LOC118567870

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Montano MM, et al. Circ Res, 2008 Feb 29. PMID 18079413, Free PMC Article
    2. Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Okamura D, et al. Genes Dev, 2012 Nov 15. PMID 23154982, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 7SK snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7SK snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables snRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein HEXIM2
    Names
    hexamthylene bis-acetamide inducible 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130515.1 → NP_001123987.1  protein HEXIM2

      See identical proteins and their annotated locations for NP_001123987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AK160110, BC026458, BI076707
      Consensus CDS
      CCDS25514.1
      UniProtKB/Swiss-Prot
      Q3TVI4, Q9D4C7
      Related
      ENSMUSP00000102652.2, ENSMUST00000107037.8
      Conserved Domains (1) summary
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    2. NM_001130516.1 → NP_001123988.1  protein HEXIM2

      See identical proteins and their annotated locations for NP_001123988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.
      Source sequence(s)
      AK160110, BC026458, BI076707
      Consensus CDS
      CCDS25514.1
      UniProtKB/Swiss-Prot
      Q3TVI4, Q9D4C7
      Conserved Domains (1) summary
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    3. NM_027658.2 → NP_081934.1  protein HEXIM2

      See identical proteins and their annotated locations for NP_081934.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      BC026458, BI076707, BY295186
      Consensus CDS
      CCDS25514.1
      UniProtKB/Swiss-Prot
      Q3TVI4, Q9D4C7
      Related
      ENSMUSP00000053678.5, ENSMUST00000062530.5
      Conserved Domains (1) summary
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      103014086..103030734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534231.4 → XP_006534294.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006534294.1

      UniProtKB/Swiss-Prot
      Q3TVI4, Q9D4C7
      Conserved Domains (1) summary
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    2. XM_006534230.4 → XP_006534293.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006534293.1

      UniProtKB/Swiss-Prot
      Q3TVI4, Q9D4C7
      Conserved Domains (1) summary
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    3. XM_006534229.3 → XP_006534292.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006534292.1

      UniProtKB/Swiss-Prot
      Q3TVI4, Q9D4C7
      Conserved Domains (1) summary
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    4. XM_030246320.1 → XP_030102180.1  protein HEXIM2 isoform X1

      UniProtKB/Swiss-Prot
      Q3TVI4, Q9D4C7
      Conserved Domains (1) summary
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein

    5. XM_006534228.3 → XP_006534291.1  protein HEXIM2 isoform X1

      See identical proteins and their annotated locations for XP_006534291.1

      UniProtKB/Swiss-Prot
      Q3TVI4, Q9D4C7
      Conserved Domains (1) summary
      pfam15313
      Location:101 → 226
      HEXIM; Hexamethylene bis-acetamide-inducible protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TVI4.1 GenPept UniProtKB/Swiss-Prot:Q3TVI4

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