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    Sun3 Sad1 and UNC84 domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 194974, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Sun3provided by MGI
    Official Full Name
    Sad1 and UNC84 domain containing 3provided by MGI
    Primary source
    MGI:MGI:3041199
    See related
    Ensembl:ENSMUSG00000040985 AllianceGenome:MGI:3041199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sunc1
    Summary
    Predicted to enable protein-membrane adaptor activity. Predicted to be involved in nuclear envelope organization. Part of meiotic nuclear membrane microtubule tethering complex. Orthologous to human SUN3 (Sad1 and UNC84 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 19.5) and kidney adult (RPKM 1.6) See more
    Orthologs
    human all
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    Genomic context

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    See Sun3 in Genome Data Viewer
    Location:
    11 A1; 11 5.77 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (8962704..8998991, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (9016043..9048991, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene polycystic kidney disease 1 like 1 Neighboring gene STARR-seq mESC enhancer starr_28552 Neighboring gene predicted gene, 57803 Neighboring gene HUS1 checkpoint clamp component Neighboring gene predicted gene 11992 Neighboring gene STARR-seq mESC enhancer starr_28553 Neighboring gene STARR-seq mESC enhancer starr_28555 Neighboring gene uridine phosphorylase 1 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide C pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis. Gao Q, et al. J Biol Chem, 2020 May 8. PMID 32156700, Free PMC Article
    2. Mammalian sperm head formation involves different polarization of two novel LINC complexes. Göb E, et al. PLoS One, 2010 Aug 10. PMID 20711465, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis.
      Title: The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130135, D630047F21Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of meiotic nuclear membrane microtubule tethering complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUN domain-containing protein 3
    Names
    Sad1 and UNC84 domain containing 1
    sad1/unc-84 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290519.1 → NP_001277448.1  SUN domain-containing protein 3 isoform a

      See identical proteins and their annotated locations for NP_001277448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK132922
      Consensus CDS
      CCDS70140.1
      UniProtKB/Swiss-Prot
      Q5SS91, Q8BHY0
      UniProtKB/TrEMBL
      E9LV81
      Related
      ENSMUSP00000045199.6, ENSMUST00000043377.6
      Conserved Domains (1) summary
      pfam07738
      Location:182 → 316
      Sad1_UNC; Sad1 / UNC-like C-terminal

    2. NM_001290520.1 → NP_001277449.1  SUN domain-containing protein 3 isoform b

      See identical proteins and their annotated locations for NP_001277449.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5'-terminal exon, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK052771
      Consensus CDS
      CCDS24430.1
      UniProtKB/Swiss-Prot
      Q5SS91
      Conserved Domains (1) summary
      pfam07738
      Location:122 → 256
      Sad1_UNC; Sad1 / UNC-like C-terminal

    3. NM_177576.3 → NP_808244.1  SUN domain-containing protein 3 isoform b

      See identical proteins and their annotated locations for NP_808244.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5'-terminal exon, lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK052771
      Consensus CDS
      CCDS24430.1
      UniProtKB/Swiss-Prot
      Q5SS91
      Related
      ENSMUSP00000099973.2, ENSMUST00000102909.8
      Conserved Domains (1) summary
      pfam07738
      Location:122 → 256
      Sad1_UNC; Sad1 / UNC-like C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      8962704..8998991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514597.5 → XP_006514660.1  SUN domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      pfam07738
      Location:180 → 314
      Sad1_UNC; Sad1 / UNC-like C-terminal

    2. XM_006514595.5 → XP_006514658.1  SUN domain-containing protein 3 isoform X1

      Conserved Domains (1) summary
      pfam07738
      Location:206 → 340
      Sad1_UNC; Sad1 / UNC-like C-terminal

    3. XM_030245703.2 → XP_030101563.1  SUN domain-containing protein 3 isoform X4

      Conserved Domains (1) summary
      pfam07738
      Location:122 → 256
      Sad1_UNC; Sad1 / UNC-like C-terminal

    4. XM_036156457.1 → XP_036012350.1  SUN domain-containing protein 3 isoform X4

      Conserved Domains (1) summary
      pfam07738
      Location:122 → 256
      Sad1_UNC; Sad1 / UNC-like C-terminal

    5. XM_006514598.4 → XP_006514661.1  SUN domain-containing protein 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SS91.1 GenPept UniProtKB/Swiss-Prot:Q5SS91

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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