Ptpa protein phosphatase 2 phosphatase activator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptpaprovided by RGD
Official Full Name: protein phosphatase 2 phosphatase activatorprovided by RGD
Primary source: RGD:1308354
See related: Ensembl:ENSRNOG00000018457 AllianceGenome:RGD:1308354
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ppp2r4
Summary: Predicted to enable several functions, including ATP binding activity; peptidyl-prolyl cis-trans isomerase activity; and protein homodimerization activity. Predicted to contribute to ATP hydrolysis activity. Predicted to be involved in mitotic spindle organization; positive regulation of apoptotic process; and regulation of phosphoprotein phosphatase activity. Predicted to be located in nucleoplasm. Predicted to be part of calcium channel complex and protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 422.8), Thymus (RPKM 400.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (34087637..34118100)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (13689742..13720287)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (8982122..9012585)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein phosphatase 2A, but not 2B, activity is downregulated following compressive injury of the cerebral cortex.
Title: Compression alters kinase and phosphatase activity and tau and MAP2 phosphorylation transiently while inducing the fast adaptive dendritic remodeling of underlying cortical neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127941 (e-PCR)
- UniSTS:211251

D3Mco30 (e-PCR)
- UniSTS:239924

RH125061 (e-PCR)
- UniSTS:161883

REN36142 (e-PCR)
- UniSTS:360942

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activator activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein dephosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ATPase complex	ISO Inferred from Sequence Orthology more info
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A activator

Names: protein phosphatase 2 regulatory subunit 4; protein phosphatase 2A activator, regulatory subunit 4; protein phosphatase 2A regulatory subunit 4; protein phosphatase 2A, regulatory subunit B (PR 53)

NP_001102047.1

EC 3.1.3.48

EC 5.2.1.8

XP_038961297.1

EC 3.1.3.48

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108577.2 → NP_001102047.1 serine/threonine-protein phosphatase 2A activator

See identical proteins and their annotated locations for NP_001102047.1

Status: PROVISIONAL

Source sequence(s)

BC166861

UniProtKB/TrEMBL

B2RYQ2, F7FF51

Related

ENSRNOP00000024914.6, ENSRNOT00000024914.6

Conserved Domains (1) summary

pfam03095
Location:26 → 316

PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

34087637..34118100

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105369.2 → XP_038961297.1 serine/threonine-protein phosphatase 2A activator isoform X1

Conserved Domains (1) summary

pfam03095
Location:26 → 229

PTPA; Phosphotyrosyl phosphate activator (PTPA) protein