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    Mug1 murinoglobulin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497794, updated on 2-May-2024

    Summary

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    Symbol
    Mug1provided by RGD
    Full Name
    murinoglobulin 1provided by RGD
    Primary source
    RGD:621366
    See related
    Ensembl:ENSRNOG00000067685 AllianceGenome:RGD:621366
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    A1i3
    Summary
    Predicted to enable endopeptidase inhibitor activity and protease binding activity. Involved in inflammatory response. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in otitis media. Orthologous to human PZP (PZP alpha-2-macroglobulin like) and A2ML1 (alpha-2-macroglobulin like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 14140.2) See more
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    Genomic context

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    See Mug1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (156748351..156802132)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (155076270..155130051)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (154676382..154729288)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene murinoglobulin 1 like 1 Neighboring gene thymosin beta-10 pseudogene Neighboring gene salvador family WW domain containing protein 1, pseudogene 1 Neighboring gene uncharacterized LOC108350756 Neighboring gene murinoglobulin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tumor-associated expression of a serum protein, termed aX protein (alpha 1-inhibitor III), and its mRNA in rat liver. Sugiyama K, et al. Jpn J Cancer Res, 1989 Aug. PMID 2511184, Free PMC Article
    2. Differential regulation of the two mRNA species of the rodent negative acute phase protein alpha 1-inhibitor 3. Regler R, et al. FEBS Lett, 1991 May 6. PMID 1709877
    3. Differential levels of Alpha-1-inhibitor III, Immunoglobulin heavy chain variable region, and Hypertrophied skeletal muscle protein GTF3 in rat mammary tumorigenesis. Ganaie IA, et al. Biochimie, 2020 Jul. PMID 32325114
    4. Sequence and acute phase regulation of rat alpha 1-inhibitor III messenger RNA. Braciak TA, et al. J Biol Chem, 1988 Mar 15. PMID 2831216
    5. Alpha-2 macroglobulin controls trophoblast positioning in mouse implantation sites. Esadeg S, et al. Placenta, 2003 Nov. PMID 14580373

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential levels of Alpha-1-inhibitor III, Immunoglobulin heavy chain variable region, and Hypertrophied skeletal muscle protein GTF3 in rat mammary tumorigenesis.
      Title: Differential levels of Alpha-1-inhibitor III, Immunoglobulin heavy chain variable region, and Hypertrophied skeletal muscle protein GTF3 in rat mammary tumorigenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo implantation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    murinoglobulin-1
    Names
    Murinoglobulin 1 homolog
    alpha x protein
    alpha-1-inhibitor III
    alpha-X protein
    murinoglobulin-1-like
    plasma proteinase inhibitor alpha-1-inhibitor III

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023103.1 → NP_075591.1  murinoglobulin-1 precursor

      See identical proteins and their annotated locations for NP_075591.1

      Status: PROVISIONAL

      Source sequence(s)
      X52984
      UniProtKB/Swiss-Prot
      Q03310, Q03626, Q63018, Q63020, Q63023, Q78DZ4, Q9JMK7
      UniProtKB/TrEMBL
      D4A6E3
      Related
      ENSRNOP00000019969.5, ENSRNOT00000019969.7
      Conserved Domains (6) summary
      cd02897
      Location:971 → 1277
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:751 → 841
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07677
      Location:1389 → 1476
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1024 → 1279
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:459 → 606
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      156748351..156802132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237282.5 → XP_006237344.1  murinoglobulin-1 isoform X1

      UniProtKB/TrEMBL
      D4A6E3
      Related
      ENSRNOP00000069175.2
      Conserved Domains (6) summary
      cd02897
      Location:971 → 1277
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:751 → 841
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07677
      Location:1389 → 1476
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1024 → 1279
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:459 → 606
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03626.1 GenPept UniProtKB/Swiss-Prot:Q03626

    Gene LinkOut

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