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    Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315220, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Mapk8ip2provided by RGD
    Official Full Name
    mitogen-activated protein kinase 8 interacting protein 2provided by RGD
    Primary source
    RGD:1309727
    See related
    Ensembl:ENSRNOG00000032828 AllianceGenome:RGD:1309727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IB-2; JIP-2
    Summary
    Predicted to enable several functions, including MAP-kinase scaffold activity; kinesin binding activity; and protein kinase activator activity. Involved in positive regulation of stress-activated MAPK cascade. Part of protein-containing complex. Orthologous to human MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 117.8), Adrenal (RPKM 16.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mapk8ip2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (122406350..122416602)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (120526732..120536982)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (130430588..130440838)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene carnitine palmitoyltransferase 1B Neighboring gene uncharacterized LOC134479955 Neighboring gene choline kinase beta Neighboring gene uncharacterized LOC134479956 Neighboring gene uncharacterized LOC120093826 Neighboring gene arylsulfatase A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Behavioral and cerebellar transmission deficits in mice lacking the autism-linked gene islet brain-2. Giza J, et al. J Neurosci, 2010 Nov 3. PMID 21048139, Free PMC Article
    2. Regulatory mechanisms of mitogen-activated kinase signaling. Zhang Y, et al. Cell Mol Life Sci, 2007 Nov. PMID 17726577, Free PMC Article
    3. Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade. Buchsbaum RJ, et al. Mol Cell Biol, 2002 Jun. PMID 12024021, Free PMC Article
    4. cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein. Negri S, et al. Genomics, 2000 Mar 15. PMID 10756100
    5. Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. Schoorlemmer J, et al. J Biol Chem, 2002 Dec 20. PMID 12244047, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables JUN kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP-kinase scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP-kinase scaffold activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mating behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nonassociative learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stress-activated MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in social behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-Jun-amino-terminal kinase-interacting protein 2
    Names
    JNK MAP kinase scaffold protein 2
    JNK-interacting protein 2
    islet-brain-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100720.3 → NP_001094190.1  C-Jun-amino-terminal kinase-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      G3V9M2, Q3B8P9
      Related
      ENSRNOP00000052648.1, ENSRNOT00000055792.3
      Conserved Domains (2) summary
      cd11942
      Location:619 → 673
      SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
      cd01212
      Location:690 → 835
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      122406350..122416602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3V9M2.1 GenPept UniProtKB/Swiss-Prot:G3V9M2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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