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    Car4 carbonic anhydrase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29242, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Car4provided by RGD
    Official Full Name
    carbonic anhydrase 4provided by RGD
    Primary source
    RGD:2242
    See related
    Ensembl:ENSRNOG00000002916 AllianceGenome:RGD:2242
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ca4
    Summary
    Enables carbonate dehydratase activity. Involved in animal organ development; response to steroid hormone; and response to xenobiotic stimulus. Located in apical plasma membrane; sarcolemma; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human CA4 (carbonic anhydrase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 349.5), Kidney (RPKM 191.9) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Car4 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70325102..70333916)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69827945..69836501)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72272286..72281069)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 4 Neighboring gene ribosomal protein L37A, pseudogene 3 Neighboring gene ubiquitin specific peptidase 32 Neighboring gene DAB adaptor protein 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regression of medial elastocalcinosis in rat aorta: a new vascular function for carbonic anhydrase. Essalihi R, et al. Circulation, 2005 Sep 13. PMID 16144999
    2. Rat embryos express transcripts for cyclooxygenase-1 and carbonic anhydrase-4, but not for cyclooxygenase-2, during organogenesis. Streck RD, et al. Birth Defects Res B Dev Reprod Toxicol, 2003 Feb. PMID 12852484
    3. Regional expression and androgen regulation of carbonic anhydrase IV and II in the adult rat epididymis. Kaunisto K, et al. Biol Reprod, 1999 Dec. PMID 10569998
    4. Membrane-associated carbonic anhydrase IV in skeletal muscle: subcellular localization. Decker B, et al. Histochem Cell Biol, 1996 Oct. PMID 8911968
    5. Pulmonary carbonic anhydrase IV: developmental regulation and cell-specific expression in the capillary endothelium. Fleming RE, et al. Am J Physiol, 1993 Dec. PMID 8279579

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Renal vascular reactivity is associated with up regulation of renal endothelin receptors type A.
      Title: Lipopolysaccharide enhanced renal vascular response to endothelin-1 through ETA overexpression in portal hypertensive rats.
    2. Vascular mineral loss induced by blockade of endothelin receptors seems dependent on activation of membrane-bound carbonic anhydrase IV. Mineral loss may proceed via local changes in pH similar to that seen in bone resorption.
      Title: Regression of medial elastocalcinosis in rat aorta: a new vascular function for carbonic anhydrase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbonate dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicarbonate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in transport vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 4
    Names
    CA-IV
    carbonate dehydratase IV
    carbonic anhydrase IV
    NP_062047.1
    XP_038941640.1
    XP_063124865.1
    XP_063124866.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019174.3 → NP_062047.1  carbonic anhydrase 4 precursor

      See identical proteins and their annotated locations for NP_062047.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P48284, Q4QR97
      UniProtKB/TrEMBL
      A0A0H2UHB3, A6HHN2
      Related
      ENSRNOP00000003908.3, ENSRNOT00000003908.6
      Conserved Domains (1) summary
      cd03117
      Location:47 → 280
      alpha_CA_IV_XV_like; Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      70325102..70333916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268796.1 → XP_063124866.1  carbonic anhydrase 4 isoform X2

    2. XM_039085712.2 → XP_038941640.1  carbonic anhydrase 4 isoform X1

      Conserved Domains (1) summary
      cl00012
      Location:1 → 190
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

    3. XM_063268795.1 → XP_063124865.1  carbonic anhydrase 4 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48284.1 GenPept UniProtKB/Swiss-Prot:P48284

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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