Svs4 seminal vesicle secretory protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Svs4provided by RGD
Full Name: seminal vesicle secretory protein 4provided by RGD
Primary source: RGD:3791
See related: Ensembl:ENSRNOG00000068526 AllianceGenome:RGD:3791
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ADP; Svp4; SVS IV; SVSIV1; RNSVSP4U
Summary: Enables identical protein binding activity and protein self-association. Located in extracellular space. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: Svs4 appears to be a redundant annotation with LOC103691965 on Rnor_6.0 (Annot. Release 105). The location where Svs4 is annotated on Rnor_6.0 is not conserved in mouse syntenic region. Annotation of Svs4 at location where LOC103691965 is currently annotated on Rnor_6.0 would be supported by mouse synteny and annotation on Rn_Celera. BLAST analysis of Svs4 NM_012662.3 against reference assembly shows high sequence identity with Svs4 (100% identity for each exon with genome) and LOC103691965 (100% identity for each exon with genome). 2-sequence BLAST analysis of Svs4 underlying component on Rnor_6.0 AABR07054533.1 and LOC103691965 underlying component AC132741.4 shows high sequence identity (100% coverage, 99% identity) across ~50 kb length of AABR07054533.1. [16 Mar 2015]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 3q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173367643..173369878, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (152948264..152950499, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (159095825..159098060)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

induces histamine release from human FcepsilonRI+ cells
Title: Antiapoptotic seminal vesicle protein IV induces histamine release from human FcepsilonRI+ cells.
findings indicate that seminal vesicle protein IV has a marked in vitro inhibitory effect on natural killer cell, lymphokine-activated killer cell and cytotoxic T lymphocyte cytotoxicity
Title: Anti-apoptotic seminal vesicle protein IV inhibits cell-mediated immunity.
native seminal vesicle protein 4 was shown by spectrophotometric and electrospray-MS analysis to interact with NADPH, an electron donor substrate of the selenium-dependent glutathione peroxidase/glutathione reductase redox system
Title: In vitro stimulatory effect of anti-apoptotic seminal vesicle protein 4 on purified peroxidase enzymes.
Data strongly suggest that SV-IV needs large plasticity to efficiently interact with the different targets that characterize its multifaceted biological function, and should therefore be better classified as an intrinsically disordered protein.
Title: Abundance of intrinsic disorder in SV-IV, a multifunctional androgen-dependent protein secreted from rat seminal vesicle.
Seminal vesicle protein 4 act as a cell survival factor, preventing apoptosis but not cell cycle arrest. May be involved in survival of implanting embryos.
Title: The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: possible implications for the survival of implanting embryo.
data show that SV-IV possesses the ability to upregulate in J774 macrophages the expression of the gene coding for the inducible nitric oxide synthase
Title: Protein SV-IV promotes nitric oxide production not associated with apoptosis in murine macrophages.

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General gene information

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Markers

D3Mgh3 (e-PCR)
- UniSTS:227533

BF416756 (e-PCR)
- UniSTS:249338

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: seminal vesicle secretory protein 4

Names: SVS protein S; Seminal vesicle protein-4; androgen-dependent protein; seminal vesicle protein 2; seminal vesicle protein 4; seminal vesicle secretory protein IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.