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    Itih3 inter-alpha trypsin inhibitor, heavy chain 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50693, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Itih3provided by RGD
    Official Full Name
    inter-alpha trypsin inhibitor, heavy chain 3provided by RGD
    Primary source
    RGD:620633
    See related
    Ensembl:ENSRNOG00000017689 AllianceGenome:RGD:620633
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PAIHC3
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of endopeptidase activity. Predicted to be located in extracellular region. Orthologous to human ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 11567.5) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itih3 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6108378..6123609, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6101922..6117154, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (6983779..7007288, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene musculoskeletal, embryonic nuclear protein 1 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 4 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1 Neighboring gene NIMA-related kinase 4 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene signal peptidase complex subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate. Kaczmarczyk A, et al. J Biol Chem, 2002 Apr 19. PMID 11827976
    2. [Interaction between hypertriglyceridemia and noise in human hearing]. Lahoz Zamarro MT, et al. Acta Otorrinolaringol Esp, 1992 Nov-Dec. PMID 1299283
    3. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
    4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate
      Title: Intracellular coupling of the heavy chain of pre-alpha-inhibitor to chondroitin sulfate.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hyaluronan metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H3
    Names
    ITI heavy chain H3
    ITI-HC3
    inter-alpha-inhibitor heavy chain 3
    pre-alpha-inhibitor, heavy chain 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017351.1 → NP_059047.1  inter-alpha-trypsin inhibitor heavy chain H3 precursor

      See identical proteins and their annotated locations for NP_059047.1

      Status: PROVISIONAL

      Source sequence(s)
      X83231
      UniProtKB/Swiss-Prot
      Q63416
      UniProtKB/TrEMBL
      A6KG20
      Related
      ENSRNOP00000023984.4, ENSRNOT00000023984.7
      Conserved Domains (4) summary
      smart00609
      Location:29 → 158
      VIT; Vault protein Inter-alpha-Trypsin domain
      TIGR03788
      Location:47 → 602
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam06668
      Location:681 → 868
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
      cl00057
      Location:281 → 462
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      6108378..6123609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275657.1 → XP_063131727.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GKX5, A6KG20

    2. XM_063275656.1 → XP_063131726.1  inter-alpha-trypsin inhibitor heavy chain H3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63416.1 GenPept UniProtKB/Swiss-Prot:Q63416

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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