Fermt2 fermitin family member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fermt2provided by MGI
Official Full Name: fermitin family member 2provided by MGI
Primary source: MGI:MGI:2385001
See related: Ensembl:ENSMUSG00000037712 AllianceGenome:MGI:2385001
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mig2; Plekhc1; Kindlin-2
Summary: Enables actin filament binding activity. Involved in several processes, including focal adhesion assembly; integrin activation; and positive regulation of osteoblast differentiation. Located in stress fiber. Is expressed in several structures, including brain ventricular layer; genitourinary system; gut; immune system; and musculature. Orthologous to human FERMT2 (FERM domain containing kindlin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 89.4), placenta adult (RPKM 48.8) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 22.97 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (45696252..45767767, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (45458792..45530310, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased extracellular matrix stiffness regulates myofibroblast transformation through induction of autophagy-mediated Kindlin-2 cytoplasmic translocation.
Title: Increased extracellular matrix stiffness regulates myofibroblast transformation through induction of autophagy-mediated Kindlin-2 cytoplasmic translocation.
Kindlin-2 maintains liver homeostasis by regulating GSTP1-OPN-mediated oxidative stress and inflammation in mice.
Title: Kindlin-2 maintains liver homeostasis by regulating GSTP1-OPN-mediated oxidative stress and inflammation in mice.
Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland.
Title: Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland.
Kindlin-2 enhances c-Myc translation through association with DDX3X to promote pancreatic ductal adenocarcinoma progression.
Title: Kindlin-2 enhances c-Myc translation through association with DDX3X to promote pancreatic ductal adenocarcinoma progression.
Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis.
Title: Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis.
Kindlin-2 inhibits TNF/NF-kappaB-Caspase 8 pathway in hepatocytes to maintain liver development and function.
Title: Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function.
[Kindlin-2 regulates endometrium development via mTOR and Hippo signaling pathways in mice].
Title: [Kindlin-2 regulates endometrium development via mTOR and Hippo signaling pathways in mice].
Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice.
Title: Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice.
Mechanosensors control skeletal muscle mass, molecular clocks, and metabolism.
Title: Mechanosensors control skeletal muscle mass, molecular clocks, and metabolism.
Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression.
Title: Kindlin-2 promotes Src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Plekhc1 (e-PCR), detects polymorphism
- UniSTS:498247

Plekhc1 (e-PCR), detects polymorphism
- UniSTS:498248

AA960555 (e-PCR)
- UniSTS:160380

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adherens junction maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in integrin activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin activation	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in limb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myosin light chain kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cell junction	ISO Inferred from Sequence Orthology more info
involved_in protein localization to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fermitin family homolog 2

Names: mitogen inducible 2; pleckstrin homology domain containing, family C (with FERM domain) member 1; pleckstrin homology domain-containing family C member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360525.2 → NP_001347454.1 fermitin family homolog 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC102445, CT025535, LXEJ02000532

UniProtKB/TrEMBL

Q3UMA4

Conserved Domains (4) summary

cd01237
Location:384 → 508

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

pfam00373
Location:520 → 584

FERM_M; FERM central domain

cl09511
Location:252 → 312

FERM_B-lobe; FERM domain B-lobe

cl17171
Location:578 → 669

PH-like; Pleckstrin homology-like domain
NM_001360526.2 → NP_001347455.1 fermitin family homolog 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC102445, CT025535, LXEJ02000532

UniProtKB/TrEMBL

Q3UMA4

Conserved Domains (4) summary

cd01237
Location:373 → 497

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

pfam00373
Location:509 → 580

FERM_M; FERM central domain

cl09511
Location:241 → 301

FERM_B-lobe; FERM domain B-lobe

cl17171
Location:574 → 665

PH-like; Pleckstrin homology-like domain
NM_001425724.1 → NP_001412653.1 fermitin family homolog 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC102445, CT025535, LXEJ02000532
NM_001425725.1 → NP_001412654.1 fermitin family homolog 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC102445, CT025535, LXEJ02000532
NM_001425726.1 → NP_001412655.1 fermitin family homolog 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC102445, CT025535, LXEJ02000532
NM_001425728.1 → NP_001412657.1 fermitin family homolog 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC102445, CT025535, LXEJ02000532
NM_001425729.1 → NP_001412658.1 fermitin family homolog 2 isoform 8

Status: VALIDATED

Source sequence(s)

AC102445, CT025535, LXEJ02000532
NM_146054.4 → NP_666166.2 fermitin family homolog 2 isoform 3

See identical proteins and their annotated locations for NP_666166.2

Status: VALIDATED

Source sequence(s)

AC102445, CT025535, LXEJ02000532

Consensus CDS

CCDS26977.1

UniProtKB/Swiss-Prot

Q8C542, Q8CIB5, Q8K035

UniProtKB/TrEMBL

Q3TLE2, Q3UMA4

Related

ENSMUSP00000044554.7, ENSMUST00000045905.15

Conserved Domains (4) summary

cd01237
Location:373 → 497

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

pfam00169
Location:381 → 476

PH; PH domain

pfam00373
Location:509 → 573

FERM_M; FERM central domain

cl17171
Location:567 → 658

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

45696252..45767767 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158558.1 → XP_036014451.1 fermitin family homolog 2 isoform X3

UniProtKB/TrEMBL

Q3UMA4

Conserved Domains (5) summary

cd01237
Location:373 → 497

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

cd17181
Location:17 → 96

FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)

cd17184
Location:97 → 277

FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)

pfam00373
Location:515 → 588

FERM_M; FERM central domain

cl17171
Location:582 → 673

PH-like; Pleckstrin homology-like domain
XM_036158557.1 → XP_036014450.1 fermitin family homolog 2 isoform X1

UniProtKB/TrEMBL

Q3UMA4

Conserved Domains (5) summary

cd01237
Location:384 → 508

PH_fermitin; Fermitin family pleckstrin homology (PH) domain

cd17181
Location:17 → 96

FERM_F0_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in kindlin-2 (KIND2)

cd17184
Location:97 → 288

FERM_F1_KIND2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in kindlin-2 (KIND2)

pfam00373
Location:526 → 599

FERM_M; FERM central domain

cl17171
Location:593 → 684

PH-like; Pleckstrin homology-like domain